济南地区产妇与其新生儿百日咳抗体水平调查

doi:10.3969/j.issn.1000-3606.2020.10.002

临床儿科杂志 ›› 2020, Vol. 38 ›› Issue (10): 726-.doi: 10.3969/j.issn.1000-3606.2020.10.002

济南地区产妇与其新生儿百日咳抗体水平调查

刘艳芹 1, 王莉 2, 于华凤 1, 杨春 1, 王冰 1, 孙静 1, 韩玉玲 1, 马香 1

1.山东大学齐鲁儿童医院（山东济南 250022）； 2.山东第一医科大学第一附属医院山东省千佛山医院（山东济南 250014）

出版日期:2020-10-15 发布日期:2020-10-10
通讯作者: 马香电子信箱：maxiang0176@163.com
基金资助:
济南市临床科技创新项目(No.201805015,?201907032)；济南市卫生和计划生育委员会科技计划项目青年计划(No.2017-2-19）

The level of antibodies to Bordetella pertussis among pregnant women and their newborns in Jinan area

LIU Yanqin1, WANG Li2, YU Huafeng1, YANG Chun2, WANG Bing1, SUN Jing1, HAN Yuling1， MA Xiang1

1.Department of Respiratory, Qilu Children’s Hospital, Cheeloo Medicine College, Shandong University, Jinan 250022, Shandong, China; 2.Department of Obstetrics and Gynecology, The First Affiliated Hospital of Shandong First Medical University, Jinan 250014, Shandong, China

Online:2020-10-15 Published:2020-10-10

摘要/Abstract

摘要： 目的　了解不同年龄产妇及其新生儿的百日咳抗体水平。方法以酶联免疫法检测100对不同年龄的健康产妇外周血及其所产新生儿的脐带血（新生儿端）的百日咳抗体水平。结果 20世纪70年代、80年代和90年代出生产妇的百日咳IgG抗体中位水平为7.99?IU/mL、5.00?IU/mL和5.71?IU/mL，三组间的差异有统计学意义（P<0.05）。产妇血清百日咳IgG抗体阴性占97%，新生儿百日咳IgG抗体阴性占92%。产妇的血清百日咳IgG抗体与其对应的新生儿脐带血的百日咳IgG抗体水平呈正相关（r=0.76， P<0.001）。结论目前产妇的百日咳抗体不能保护产妇免于百日咳感染，同时胎传抗体的保护作用弱，可以考虑进一步调整免疫接种策略以预防百日咳。

关键词: 百日咳；流行病学；产妇；新生儿

Abstract: Objective? To?explore?the?pertussis?antibody?levels?of?mothers?of?different?ages?and?their?newborns.? Methods Enzyme-linked?immunosorbent?assay?was?used?to?detect?the?pertussis?antibody?levels?in?the?peripheral?blood?of?100? pairs?of?healthy?mothers?of?different?ages?and?the?umbilical?cord?blood?(newborn?side)?of?their?newborns.?Results The median levels?of?pertussis?IgG?antibodies?in?women?born?in?the?1970s,?1980s?and?1990s?were?7.99?IU/mL,?5.00?IU/mL?and?5.71?IU/ mL,?respectively,?and?the?difference?among?the?three?groups?were?statistically?significant?(P<0.05).?Serum?pertussis?IgG?antibody? was?negative?in?97%?of?the?mothers?and?negative?in?92%?of?the?newborns.?There?was?a?positive?correlation?between?maternal? serum?pertussis?IgG?antibody?levels?and?neonatal?umbilical?cord?blood?pertussis?IgG?antibody?levels?(r=0.76， P<0.001).? Conclusion? Current?maternal?pertussis?antibodies?cannot?protect?women?from?pertussis?infection,?and?the?protective?effect?of?fetal? antibodies?obtained?from?the?mother?is?weak.?Further?adjustment?of?immunization?strategies?to?prevent?pertussis?may?be?considered.?

Key words: pertussis; epidemiology; parturient; neonate

刘艳芹，王莉，于华凤，等. 济南地区产妇与其新生儿百日咳抗体水平调查[J]. 临床儿科杂志, 2020, 38(10): 726-.

LIU Yanqin, WANG Li, YU Huafeng, et al. The level of antibodies to Bordetella pertussis among pregnant women and their newborns in Jinan area[J]. Journal of Clinical Pediatrics, 2020, 38(10): 726-.

济南地区产妇与其新生儿百日咳抗体水平调查

The level of antibodies to Bordetella pertussis among pregnant women and their newborns in Jinan area

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