临床儿科杂志 ›› 2015, Vol. 33 ›› Issue (8): 734-.doi: 10.3969 j.issn.1000-3606.2015.08.013

• 综合报道 • 上一篇    下一篇

早产儿血清维生素A 水平与新生儿呼吸窘迫综合征的相关性分析

程晨,包蕾   

  1. 重庆医科大学附属儿童医院新生儿科 儿童发育疾病研究教育部重点实验室 儿科学重庆市重点实验室 重庆市儿童发育重大疾病诊治与预防国际科技合作基地( 重庆 400014)
  • 收稿日期:2015-08-15 出版日期:2015-08-15 发布日期:2015-08-15
  • 通讯作者: 包蕾 E-mail:cqbl0046@163.com

The correlation between serum concentration of vitamin A and NRDS in preterm infants

CHENG Chen, BAO Lei   

  1. Children’s Hospital of Chongqing Medical University, Chongqing 400014, China
  • Received:2015-08-15 Online:2015-08-15 Published:2015-08-15

摘要:  目的 观察早产儿血清维生素A(VA)水平与新生儿呼吸窘迫综合征(NRDS)发生以及病情严重程度的相关性。方法 入选166例早产儿作为研究对象,比较不同VA水平下NRDS的患病率;以病例对照方法,根据不同胎龄分层时,比较NRDS及相匹配的非NRDS患儿血清VA水平的差异;比较NRDS患儿中,胸片显示轻症与重症患儿血清VA水平的差异。结果 在166例早产儿中,65例血清VA<0.35 μmol/L,其中14例患NRDS,NRDS患病率为21.54%;93例VA0.35~0.7 μmol/L,15例患NRDS,患病率为16.13%;8例VA≥0.7 μmol/L,1例患NRDS,患病率为12.5%,不同VA水平早产儿间NRDS的患病率差异无统计学意义(P>0.05)。在34~37周胎龄时,NRDS组血清VA水平低于对照组,差异有统计学意义(P<0.05);NRDS患儿中,胸片示轻症与重症者之间,VA水平的差异无统计学意义(P>0.05)。结论 VA缺乏的晚期早产儿更容易发生NRDS。

Abstract:  Objectives To observe correlation between serum vitamin A status and prevalence or severity of NRDS. Methods Recruited into this study were 166 preterm infants admitted to our neonatal department. The serum concentration of vitamin A was measured, and the prevalence of NRDS at different levels of vitamin A was compared. According to the clinical manifestation and X-rays, there were 30 infants diagnosed as NRDS. Another 30 patients from the rest 133 infants without NRDS were randomly selected as control group according to the gestational ages, then the difference between NRDS group and control group were observed according to gestational ages. The 30 preterm infants with NRDS were divided further into mild group (including stages Ⅰ and Ⅱ , n=18) and severe group (including stage Ⅲ and Ⅳ , n=12) according to findings chest X-ray, then the difference between these two groups were observed. Results In the 166 preterm infants recruited, 65/166 had serum vitamin A lower than 0.35 μmol/L, in which 14/65 (21.54%) were NRDS patients. Another 93/166 patients had serum vitamin A ranged from 0.35 μmol/L to 0.7 μmol/L, in which 15/93 (16.13%) were NRDS patient. The rest 8/166 had serum vitamin A higher than 0.7 μmol/L, in which 1/8 (12.50%) were NRDS patient. However, the differences between each two groups were not significant. When gestational ages ranged from 34 to 37 weeks, the serum concentrations of vitamin A of NRDS group were lower than that in controls (P<0.05). No significant difference between the serum concentrations of vitamin A and the severity of NRDS were observed (P>0.05). Conclusions The prevalence of NRDS for those preterm infants lacking of vitamin A was tended to increase. And the late preterm infants (34 w ≤ GA <37 w) with vitamin A deficiency are prone to NRDS.