Journal of Clinical Pediatrics ›› 2022, Vol. 40 ›› Issue (11): 864-868.doi: 10.12372/jcp.2022.22e0462

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Clinical characteristics and related factors of pulmonary involvements in patients with systemic juvenile idiopathic arthritis

TAN Xiaohua, LI Caifeng(), ZHAO Wenjia, KUANG Weiying, DENG Jianghong, ZHANG Junmei   

  1. Department of Rheumatology, Beijing Children's Hospital Affiliated to Capital Medical University, Beijing 100045, China
  • Received:2022-04-18 Online:2022-11-15 Published:2022-11-10
  • Contact: LI Caifeng E-mail:caifeng_li@yeah.net

Abstract:

Objective To investigate the clinical characteristics and related factors of systemic juvenile idiopathic arthritis (sJIA) complicated with lung involvement. Methods The clinical data of children who were initially diagnosed with sJIA from January 2017 to January 2022 were retrospectively analyzed. Results A total of 73 children (40 boys and 33 girls) with sJIA were enrolled and the median age was 5.6 (3.1-8.8) years. There were 32 children in sJIA group without lung involvement and 41 children in sJIA group with lung involvement. Compared with sJIA group without lung involvement, the proportion of sJIA combined with macrophage activation syndrome, fatigue, chest tightness and rapid shallow breathing was higher, the level of IL-18 was higher, and the proportion of positive changes in chest radiography and lung high-resolution CT was higher, and the differences were statistically significant (P<0.05). The results of binary logistics regression analysis showed that fatigue, chest tightness, positive changes of chest radiograph and lung high-resolution CT, and increased IL-18 level were independent risk factors for sJIA complicated with lung involvement (P<0.05). Conclusion Early clinical symptoms, serum IL-18 level and pulmonary imaging examination have certain predictive value for the occurrence of sJIA complicated with lung involvement.

Key words: systemic juvenile idiopathic arthritis, lung involvement, clinical characteristics, related factor