Journal of Clinical Pediatrics ›› 2020, Vol. 38 ›› Issue (10): 726-.doi: 10.3969/j.issn.1000-3606.2020.10.002

Previous Articles     Next Articles

The level of antibodies to Bordetella pertussis among pregnant women and their newborns in Jinan area

LIU Yanqin1, WANG Li2, YU Huafeng1, YANG Chun2, WANG Bing1, SUN Jing1, HAN Yuling1, MA Xiang1   

  1. 1.Department of Respiratory, Qilu Children’s Hospital, Cheeloo Medicine College, Shandong University, Jinan 250022, Shandong, China; 2.Department of Obstetrics and Gynecology, The First Affiliated Hospital of Shandong First Medical University, Jinan 250014, Shandong, China
  • Online:2020-10-15 Published:2020-10-10

Abstract: Objective? To?explore?the?pertussis?antibody?levels?of?mothers?of?different?ages?and?their?newborns.? Methods Enzyme-linked?immunosorbent?assay?was?used?to?detect?the?pertussis?antibody?levels?in?the?peripheral?blood?of?100? pairs?of?healthy?mothers?of?different?ages?and?the?umbilical?cord?blood?(newborn?side)?of?their?newborns.?Results The median levels?of?pertussis?IgG?antibodies?in?women?born?in?the?1970s,?1980s?and?1990s?were?7.99?IU/mL,?5.00?IU/mL?and?5.71?IU/ mL,?respectively,?and?the?difference?among?the?three?groups?were?statistically?significant?(P<0.05).?Serum?pertussis?IgG?antibody? was?negative?in?97%?of?the?mothers?and?negative?in?92%?of?the?newborns.?There?was?a?positive?correlation?between?maternal? serum?pertussis?IgG?antibody?levels?and?neonatal?umbilical?cord?blood?pertussis?IgG?antibody?levels?(r=0.76, P<0.001).? Conclusion? Current?maternal?pertussis?antibodies?cannot?protect?women?from?pertussis?infection,?and?the?protective?effect?of?fetal? antibodies?obtained?from?the?mother?is?weak.?Further?adjustment?of?immunization?strategies?to?prevent?pertussis?may?be?considered.?

Key words: pertussis; epidemiology; parturient; neonate