Journal of Clinical Pediatrics ›› 2020, Vol. 38 ›› Issue (10): 749-.doi: 10.3969/j.issn.1000-3606.2020.10.007

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Clinical analysis of metabolic bone disease in 6 premature infants with fracture

LIU Yingli, ZHOU Lin, ZHANG Yonghong, TAN Jintong, ZHAO Dongying, XU Min, XIA Hongping   

  1. Department of Neonatology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China
  • Online:2020-10-15 Published:2020-10-10

Abstract: Objective? To?explore?the?clinical?features?of?metabolic?bone?disease?with?fracture?in?preterm?infants.? Method? The?clinical?data?of?metabolic?bone?disease?with?fractures?in?6?neonates?admitted?from?January?2016?to?April?2020?were? retrospectively?analyzed.?Results? Among?the?6?newborns?(5?boys?and?one?girl),?the?median?gestational?age?was?27.1?weeks,? and?the?median?birth?weight?was?900?g.?Among?the?6?newborns,?multiple?costal?fractures?occurred?in?one?case,?left?humeral? fracture?occurred?in?one?case,?left?femoral?fracture?occurred?in?two?cases,?femoral?and?humeral?fracture?occurred?in?two?cases,? and?right?humeral?fracture?occurred?in?one?case.?The?blood?phosphorus?of?the?6?newborns?were?all?<1.8?mmol/L,?and?the?blood? alkaline?phosphatase?were?all?>600?IU/L,?and?the?blood?calcium?were?in?the?normal?range.?All?the?6?neonates?were?complicated? with?retinopathy?of?prematurity?and?bronchopulmonary?dysplasia,?and?one?was?complicated?with?necrotizing?enterocolitis.?After? active?treatment?with?calcium,?phosphorus?and?vitamin?D3,?6?neonates?were?discharged?from?hospital?after?recovery?from?fracture.? Conclusion? Premature?infants?with?very?low?birth?weight?should?pay?attention?to?avoid?metabolic?osteopathy?complicated?with? fracture.

Key words: metabolic?bone?disease;? fracture;? alkaline?phosphatase;? premature?infant