临床儿科杂志 ›› 2020, Vol. 38 ›› Issue (9): 711-.doi: 10.3969/j.issn.1000-3606.2020.09.017

• 文献综述 • 上一篇    

新生儿高胆红素血症光疗不良反应研究进展

冯霄 1 综述, 童笑梅 2 审校   

  1. 1. 北京大学国际医院儿科(北京 102206);2. 北京大学第三人民医院(北京 100191)
  • 发布日期:2020-09-17

Research progress on adverse reactions of phototherapy for neonatal hyperbilirubinemia

 Reviewer: FENG Xiao1, Reviser: TONG Xiaomei2   

  1. 1.Peking University International Hospital, Beijing 102206, China; 2. Peking University Third Hospital, Beijing 100191, China
  • Published:2020-09-17

摘要: 光疗作为一种有效的新生儿高胆红素血症的治疗手段,在临床得到广泛应用。最近研究显示,新生儿期光疗 可通过氧化应激、DNA损伤等机制增加极低出生体质量儿病死率,并与儿童期肿瘤、黑色素痣、过敏性疾病及癫痫等有相 关联系。因此需要进一步探索和优化光疗光源设备、改变光疗方式等,减少光疗的不良反应。文章就新生儿高胆红素血症 光疗的不良反应研究进展进行综述。

关键词:  高胆红素血症; 光疗; 不良反应; 新生儿

Abstract:  As an effective treatment of neonatal hyperbilirubinemia, phototherapy has been widely applied in clinic. Recent studies have shown that neonatal phototherapy can increase the mortality of extremely low birth weight infants through such mechanisms as oxidative stress and DNA damage, and is related to childhood tumors, melanoma, allergic diseases and epilepsy. Therefore, it is necessary to further explore and optimize the light source devices and change the phototherapy approaches, etc., to reduce the adverse reactions of phototherapy. This article reviews the research progress of the adverse reactions of neonatal hyperbilirubinemia phototherapy.

Key words: hyperbilirubinemia; phototherapy; side effect; neonate