呼吸道合胞病毒毛细支气管炎患儿炎症递质的变化

临床儿科杂志 ›› 2014, Vol. 32 ›› Issue (2): 115-117.

呼吸道合胞病毒毛细支气管炎患儿炎症递质的变化

陈秋芳¹, 张海邻², 余刚², 陈小芳², 温怀凯², 李锦燕², 李昌崇²

1.濮阳市油田总医院儿科（河南濮阳　457001）；
2.温州医科大学附属育英儿童医院呼吸内科（浙江温州　325027）

收稿日期:2013-06-30 出版日期:2014-02-15 发布日期:2014-02-15

Mediators of inflammation in children with respiratory syncytial virus bronchiolitis

CHEN Qiufang¹， ZHANG Hailin²， YU Gang²， CHEN Xiaofang²， WEN Huaikai²， LI Jinyan²， LI Changchong²

(1.Department of Pediatrics， Puyang Oil Field General Hospital， Puyang 457001， Henan， China; 2. Department of Respiratory Medicine， Yuying Children's Hospital Affiliated to Wenzhou Medical University， Wenzhou 325027， Zhejiang， China)

Received:2013-06-30 Online:2014-02-15 Published:2014-02-15

摘要/Abstract

摘要：

　目的　研究气道炎症递质鼻咽分泌物嗜酸粒细胞阳离子蛋白（NPS-ECP）和尿白三烯E₄（LTE₄）在呼吸道合胞病毒（RSV）毛细支气管炎患儿体内的变化。方法　120例RSV检测阳性毛细支气管炎住院患儿，分为特应性组和非特应性组；同时选取30名健康体检儿童作为对照组。以酶联免疫吸附试验（ELISA）检测尿LTE₄浓度，UniCAP100变态反应检测仪检测患儿鼻咽分泌物中ECP浓度，比较各组间的差异。结果　特应性组尿LTE₄水平为（172.21±67.29）pg/ml，高于非特应性组的（78.21±28.78）pg/ml和正常对照组的（44.22±16.14）pg/ml，三组间差异有统计学意义（F=97.33，P<0.01）；两两比较差异也均有统计学意义（P均<0.01）。RSV毛细支气管炎患儿尿LTE₄与血浆IgE、鼻咽分泌物ECP水平均呈显著正相关（r=0.57、0.49，P均<0.01）。结论　尿LTE₄和鼻咽分泌物ECP可为RSV毛细支气管患儿的治疗和预后提供参考。

Abstract: 　Objectives　To investigate the clinical significance of the airway inflammation mediators， eosinophil cationic protein (ECP) and urinary leukotriene E4 (LTE4)， in children with respiratory syncytial virus (RSV) bronchiolitis. Methods A total of 120 inpatients with RSV bronchiolitis were classified into atopic and non-atopic groups. And 30 healthy subjects were selected as normal controls. Urinary LTE4 was determined by ELISA and ECP concentration in nasopharyngeal secretions (NPS) was tested by UniCAP100 allergen detector. The differences among groups were compared. Results The urinary LTE4 level in atopic group (172.21±67.29 pg/ml) was elevated significantly (P<0.01) than that of non-atopic group (78.21±28.78 pg/ml) and control group (44.22±16.14pg/ml). Significance was also found between non-atopic and control groups (P<0.01). Statistical analysis indicated that urinary LTE4 positively correlated to serum IgE and ECP in children with RSV bronchiolitis (r=0.57，0.49; P<0.01). Conclusions The level of urinary LTE4 and ECP in NPS can provide the reference for treatment and prognosis of children with RSV bronchiolitis. #br#Key words：　respiratory syncytial virus;　bronchiolitis;　leukotrienes;　eosinophil cationic protein;　children#br#

陈秋芳, 张海邻, 余刚, 陈小芳, 温怀凯, 李锦燕, 李昌崇. 呼吸道合胞病毒毛细支气管炎患儿炎症递质的变化[J]. 临床儿科杂志, 2014, 32(2): 115-117.

CHEN Qiufang,ZHANG Hailin,YU Gang,CHEN Xiaofang,WEN Huaikai,LI Jinyan,LI Changchong. Mediators of inflammation in children with respiratory syncytial virus bronchiolitis [J]. , 2014, 32(2): 115-117.