高敏C-反应蛋白与免疫功能检测在肺炎支原体肺炎中的意义

临床儿科杂志 ›› 2014, Vol. 32 ›› Issue (5): 456-458.

高敏C-反应蛋白与免疫功能检测在肺炎支原体肺炎中的意义

楚文英，徐慧，高淑青，姜采荣

包头市第四医院儿科（内蒙古包头　014030）

收稿日期:2013-12-27 出版日期:2014-05-15 发布日期:2014-05-15

Clinical significance of high sensitive C-reactive Protein and immune function in children with Mycoplasma Pneumoniae Pneumonia

Chu Wenying, Xu Hui, Gao Shuqing, Jiang Cairong

(Department of Pediatrics, the Fourth Hospital of Baotou, Baotou 014030, Inner Mongolia Autonomous Region, China)

Received:2013-12-27 Online:2014-05-15 Published:2014-05-15

摘要/Abstract

摘要：

　目的　探讨高敏C-反应蛋白（hs-CRP）联合免疫功能检测在儿童肺炎支原体肺炎（MPP）中的临床意义。方法　选取单纯MPP患儿103例，分为全身炎症反应综合征（SIRS）组47例和非SIRS组56例，另取26例健康儿童作为对照组，检测hs-CRP、体液免疫指标及细胞免疫指标。结果　SIRS组和非SIRS组的血清hs-CRP、IgG、IgM、CD8⁺水平显著高于对照组，而IgA、CD3⁺、CD4⁺、CD4⁺/CD8⁺水平显著低于对照组，差异均有统计学意义（P<0.05）；SIRS组的hs-CRP、IgG显著高于非SIRS组，而IgA、CD3⁺、CD4⁺、CD4⁺/CD8⁺水平则显著低于非SIRS组，差异均有统计学意义（P<0.05）；SIRS组和非SIRS组的IgM与CD8⁺水平的差异则无统计学意义（P>0.05）。结论　MPP患儿的体液免疫及细胞免疫功能均有紊乱，且与病情有关；hs-CRP有助于判断儿童MPP病情程度。

Abstract: 　Objective　To detect the clinical significance of high sensitive C-reactive Protein (Hs- CRP) and immune function in children with mycoplasma pneumoniae pneumonia (MPP). Methods 103 children with MPP, 47 cases of systemic inflammatory resPonse syndrome (SIRS group), 56 cases of non- systemic inflammatory resPonse syndrome (non-SIRS group) were recruited. 26 healthy children served as the control grouP. ELISA was used to detect the level of serum Hs- CRP, immune indexes, IgG, IgA, and IgM, Cellular immune CD3⁺, CD4⁺, CD8⁺, CD4⁺/CD8⁺. Results The level of serum Hs- CRP、IgG、IgM and CD8⁺ in control grouP were significantly lower than those in non-SIRS group and SIRS group (P<0.05). The level of IgA、CD3⁺,CD4⁺, CD4⁺/CD8⁺in control grouP were significantly higher than those in non-SIRS grouP and SIRS group (P<0.05). The level of serum Hs- CRP、IgG in SIRS group were significantly higher than those in non-SIRS group (P<0.05). The level of IgA、CD3⁺、CD4⁺、CD4⁺/CD8⁺ in SIRS grouP were significantly lower than those in non-SIRS group. There was no significant difference in non-SIRS group and SIRS group of IgM and CD8+（P>0.05）. The level change of serum hs-CRP were positively related with IgG (r=0.66， P=0.001) and were negatively related with IgA、CD4⁺、CD4⁺/CD8⁺ (r= 0.79, 0.67, 0.82, P all were< 0.05) in children with MPP. Conclusion Children with MPP have Immunity function（ including humoral immunity and cellular immunity ）disorder which is related to the disease status. The level of Hs - CRP could be an anpation index for the severity and immune function of the children with MPP.

楚文英，徐慧，高淑青，姜采荣. 高敏C-反应蛋白与免疫功能检测在肺炎支原体肺炎中的意义[J]. 临床儿科杂志, 2014, 32(5): 456-458.

Chu Wenying,Xu Hui,Gao Shuqing,Jiang Cairong. Clinical significance of high sensitive C-reactive Protein and immune function in children with Mycoplasma Pneumoniae Pneumonia [J]. , 2014, 32(5): 456-458.

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