临床儿科杂志 ›› 2014, Vol. 32 ›› Issue (5): 491-493.

• 文献综述 • 上一篇    下一篇

IL-33与儿童常见自身免疫性疾病关系的研究进展

张春霞,陈柏谕综述   

  1. 内蒙古医科大学附属医院儿科(内蒙古呼和浩特 010059);
  • 收稿日期:2013-11-09 出版日期:2014-05-15 发布日期:2014-05-15

Relationship between IL-33 and children autoimmune disease 

Reviewer: ZHANG Chunxia, CHEN Baiyu    

  1. (Department of Pediatric, the Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010059, China )
  • Received:2013-11-09 Online:2014-05-15 Published:2014-05-15

摘要:

IL-33是在2005年作为孤儿受体ST2的配体被发现的IL-1类细胞因子家族新成员,在自身免疫性疾病、变态反应性疾病、心血管性疾病、炎症性疾病等疾病中具有潜在的致病作用,并且对此类疾病的诊断及其预后判断有一定的作用。文章就对IL-33及其与自身免疫性疾病密切相关性的研究进展作一综述。

Abstract: Interleukin-33 is regarded as the orphan receptor ST2 that belongs to the cytokine family of Interleukin-1 in 2005. IL-33 is found to play a potentially pathogenic roles in the autoimmune disease, allergic disease, vascular disease, inflammatory disease and it might be a useful sera marker for the diagnosis and prognosis in related diseases. Here we make a review on the relationship between IL-33 and autoimmune disease in recent years