利奈唑胺治疗儿童重症革兰阳性菌感染的回顾性分析

临床儿科杂志 ›› 2014, Vol. 32 ›› Issue (6): 559-561.

利奈唑胺治疗儿童重症革兰阳性菌感染的回顾性分析

居艾提·色依提¹, 崔云芝², 多里坤·木扎帕尔³

1.新疆哈密地区妇幼保健所（新疆哈密　839000）；2.新疆哈密地区第二人民医院（新疆哈密 839000）　3.新疆医科大学第一附属医院（新疆乌鲁木齐　830054）

收稿日期:2014-01-27 出版日期:2014-06-15 发布日期:2014-06-15

Retrospective analysis the effect of linezolid on severe Gram-positive bacteria infection in children

JUAITI Seyiti¹, CUI Yunzhi², DUOLIKUN Muzhapaer³

(1. Hami Maternal and Child Care Service Centre, Hami 839000, Xinjiang, China; 2. The Second People's Hospital, Hami 839000, Xinjiang, China; 3. The First Hospital Affiliated to Xinjiang Medical University, Urumqi 830054, Xinjiang, China)

Received:2014-01-27 Online:2014-06-15 Published:2014-06-15

摘要/Abstract

摘要：

　目的　探讨利奈唑胺治疗儿童重症革兰阳性菌感染的临床效果。方法　回顾性分析以经验用药治疗无效而根据痰培养及药敏试验结果换用利奈唑胺治疗的重症革兰阳性菌感染患儿的临床资料。结果　24例重症革兰阳性菌感染患儿经静脉滴注利奈唑胺（10 mg/kg，q8 h），疗程10~14 d，均显效或好转。结论　在经验用药治疗无效时，选择利奈唑胺单用或联合其他药物治疗儿童重症革兰阳性菌感染可取得满意的临床效果。

Abstract: 　Objective　To investigate the clinical effect of linezolid on severe Gram-positive bacteria infection in children. Methods The retrospective analysis was performed in the clinical cases of severe Gram-positive bacteria infection which were insensitive to drugs selected from experience but sensitive to linezolid according to sputum culture and sensitivity test. Results Twenty-four children with severe Gram-positive bacterial infections were treated with linezolid by intravenous infusion (10 mg/kg, q8h) for 10-14 days. All of them were markedly improved. Conclusions When drugs selected from experiences are ineffective, linezolid or in combination with other drugs is a good choice in the treatment of severe Gram-positive bacterial infections.

居艾提·色依提, 崔云芝, 多里坤·木扎帕尔. 利奈唑胺治疗儿童重症革兰阳性菌感染的回顾性分析[J]. 临床儿科杂志, 2014, 32(6): 559-561.

JUAITI Seyiti,CUI Yunzhi,DUOLIKUN Muzhapaer. Retrospective analysis the effect of linezolid on severe Gram-positive bacteria infection in children[J]. , 2014, 32(6): 559-561.