Abstract: Objective To explore the factors related to vasovagal syncope (VVS) in children. Methods The clinical data of 125 children with confirmed VVS were collected. According to the frequency of syncope during the five years from first episode to the time of head-up tilt test, the children with 2 or 3 episodes of syncope were assigned into the low episode group, and the children with 4 or more episodes of syncope were assigned into the high episode group. The two groups were analyzed and compared. Results Among the 125 children, 84 children (67.2%) were in the low episode group and 41 children (32.8%) were in the high episode group. The single factor analysis showed that the age at head-up tilt test, onset of syncopal, causes of syncope, history of carsickness, and positive family history were associated with high attack frequency. The results of non-conditional logistic regression analysis showed that causes of syncope (OR = 3.723, 95% CI: 1.163-11.918, P = 0.027), history of carsickness (OR = 5.929, 95% CI: 2.066-17.015, P = 0.001), and positive family history (OR = 6.794, 95% CI: 2.006-23.013, P = 0.002) were the independent risk factors of high attack frequency. Conclusions The causes of syncope (excluding persistent standing), history of carsickness, and positive family history have important clinical significance in predicting high attack frequency of VVS in children.