Abstract: Objective　To analyze the clinical characteristics of children with hand, foot, and mouth disease (HFMD) combined with Kawasaki disease (KD). Methods　Clinical data of 7 pediatric patients with HFMD combined KD were retrospectively analyzed from June 2013 to June 2015. Results　Among this 7 patients, 5 patients were with bulbar conjunctival congestion and 6 patients were with cracked lips and strawberry-like tongue. Two patients met the diagnostic criteria of typical KD, 5 cases met the diagnostic criteria of incomplete KD. The testing results of cerebrospinal fluid from 7 patients all were consistent with viral encephalitis. There were 5 patients with EV71 positive, one patient with CVA16 positive. Six patients had coronary arterial lesions, two patients with right bundle branch block. Conclusion　Most of the children with HFMD combined KD was incomplete KD, complicated with central nervous system infections and coronary arterial lesions.