过敏性紫癜患儿血清IgA型抗内皮细胞抗体与细胞间黏附分子-1相关性初探

›› 2014, Vol. 32 ›› Issue (1): 12-14.

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Analysis of correlation between IgA-AECA and ICAM-1 in children with Henoch-Sch?nlein purpura　CHEN Baiyu, YANG Guanglu, REN Shaomin (Department of Pediatrics, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010059, Inner Mongolia, China)

Received:2013-08-08 Online:2014-01-15 Published:2014-01-15

Abstract

Abstract: 　Objectives　To detect the levels of anti-endothelial cell IgA antibodies (IgA-AECA) and intercellular adhesion molecule-1 (ICAM-1) in children with Henoch-Sch?nlein purpura, and to analyze the correlation between IgA-AECA and ICAM-1. Methods A total of 36 children with HSP were enrolled， 26 without renal impairment (HSP group), and 10 with renal impairment (HSPN). The concentrations of IgA-AECA and ICAM-1 in serum were detected by enzyme linked immunosorbent assay (ELISA). Results The serum levels of IgA-AECA and ICAM-1 in HSPN group were significantly higher than those in HSP group (P<0.01). The serum level of IgA-AECA showed positive correlation with the level of ICAM-1 (r=0.746, P<0.01). Conclusions IgA-AECA may play an important role in the development of HSP and HSPN by up-regulating the express of ICAM-1.

References

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Analysis of correlation between IgA-AECA and ICAM-1 in children with Henoch-Sch?nlein purpura　CHEN Baiyu, YANG Guanglu, REN Shaomin (Department of Pediatrics, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010059, Inner Mongolia, China)

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Analysis of correlation between IgA-AECA and ICAM-1 in children with Henoch-Sch?nlein purpura CHEN Baiyu, YANG Guanglu, REN Shaomin (Department of Pediatrics, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010059, Inner Mongolia, China)

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Analysis of correlation between IgA-AECA and ICAM-1 in children with Henoch-Sch?nlein purpura　CHEN Baiyu, YANG Guanglu, REN Shaomin (Department of Pediatrics, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010059, Inner Mongolia, China)