Abstract: 　Objective　To explore the relationship between hypoalbuminemia and prognosis in newborns with disseminated intravascular coagulation (DIC). Methods A total of 142 newborns diagnosed with DIC were divided into normal albumin group (≥30 g/L) and hypoalbuminemia group (<30 g/L) according to the albumin levels within 24 hours of admission. Moreover, the relationship between albumin levels and clinical manifestation, laboratory indices and prognosis of newborns with DIC were analyzed. Results The occurrence rate of hypoalbuminemia in 142 DIC newborns was 68.3% (97/142). The mortality of newborns with DIC in hypoalbuminemia group was 42.3%, significantly higher than that of normal albumin group (22.2%) (P<0.05). Compared with normal albumin group, in hypoalbuminemia group, the rates of shock and multiple organ dysfunction were significantly higher, the prothrombin time (PT) and activated partial thromboplastin time (APTT) were significantly longer, and the platelet count (PLT) was significantly reduced (P<0.05). The level of serum albumin in non-survived group was sinificantly lower than that of the survived group (P<0.05). Conclusions Hypoalbuminemia is common among newborns with DIC, and serum albumin level is closely related to the prognosis.