Abstract: 　Objective　To explore the effects of hypertensive disorder complicating pregnancy (HDCP) and premature rupture of membranes (PROM) on neonatal outcomes Methods　A total of 60 615 infants born in 151 hospitals in Huai'an from Jan 2010 to Dec 2010 were divided into differenct groups based on the presence of the HDCP and PROM. The clinical data were recorded and compared. Results　The gestational age and birth weight in HDCP group were significantly lower than those in non-HDCP group (P<0.05). The maternal age and the incidence rates of pregnant anemia, preterm, low birth weight, cesarean section, abnormal amniotic fluid, congenital anomalies, asphyxia, intracranial hematoma and case fatality rate were significantly higher in HDCP group than those in non-HDCP group (P<0.05). The gestational age and birth weight in PROM group were significantly lower than those in non-PROM group (P<0.05). The incidence rates of preterm, low birth weight, abnormal amniotic fluid, mild asphyxia, hypertensive disorder, pregnant anemia were significantly higher in PROM group than those in non-PROM group (P<0.05). Conclusions　HDCP and PROM may have severe impacts on neonatal outcomes.