Abstract: 　Objectives　To explore the relevant factors of liver X receptor (LXR) and lipid metabolism in school-age children with obesity. Methods A total of 80 obese children were selected by indexes of physical growth from pupils in Grades 1-6, aged 7-14 years from June 2011 to October 2011. Fifty-one age and sex matched children with normal BMI were chosen as normal controls. The metabolic indexes including aspartate transaminase (AST), alanine aminotransferase (ALT), glutamyl transpeptidase (GGT), total cholesterol (CHOL), triacylglycerol (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C) and expression of LXR were detected in fasting blood. Results The expression level of LXR in obese children (9.14±1.15) was higher than that in control children (2.84±3.68) with significant difference (t=4.55，P=0.000). Eighty percent (80%) of obese children were LXR> 1 (64/80) which was higher than that of control children (23/51, 45.1%), and significant difference was found between the two groups (χ²=17.01, P=0.000). Compared to controls, the levels of AST, ALT, GGT, CHOL, TG and LDL-C were higher while the level of HDL-C was lower in obese children (P<0.05). The correlation analysis found that AST, ALT, CHOL, LDL-C and BMI were positively correlated with LXR (r=0.18~0.26，P<0.05). Logistic regression ana-lysis showed that AST ≥40IU/L (OR=1.076), ALT≥40IU/L (OR=1.036), CHOL ≥5.20 mmol/L (OR=2.038), LDL-C ≥3.36 mmol/L (OR=2.176) and BMI ≥18.9 kg/m² (OR=1.131) were risk factors for LXR>1 (P<0.05). Conclusions Obesity in school-age children can up-regulate the expression of liver X receptor and cause liver damage and abnormal lipids metabolism.