›› 2014, Vol. 32 ›› Issue (2): 167-169.

• Original Article • Previous Articles     Next Articles

Influence of congenital human cytomegalovirus infection on hepatitis B vaccine's immune effect 

HAN Qijun1,WEN Tianlian2, SHEN Guohong2, GUAN Changli2, DOU Dongdong2    

  1. (1.Weifang Medical College, Weifang 261053, Shandong, China; 2.Jinan Central Hospital Affiliated to Shandong University, Jinan 250013, Shandong, China)
  • Received:2013-08-08 Online:2014-02-15 Published:2014-02-15

Abstract:  Objectives To investigate the immune effect of hepatitis B vaccine under the influence of congenital human cytomegalovirus (HCMV) infection. Methods The newborn rat model of congenital HCMV infection was developed by intraperitoneally inoculating pregnant rat with HCMV suspension,while the offsprings of healthy rats were used as the control group. Offspring rats in all groups were inoculated with hepatitis B vaccine in the postnatal 1st, 3rd and 5th week and were taken blood from hearts separately in 3rd, 5th, 7th and 11th week. Antibody to Hepatitis B surface antigen (HBsAb) titer in all groups was detected by ELISA method. Results The serum HBsAb titer in both groups all showed a trend of increasing gradually with added vaccinating times and decreased differently with time extending after completed vaccinations. Differences among changes of HBsAb titer along with prolonged time in each group were all statistically significant (P < 0.001). At all time points (3rd, 5th, 7th, 11th week), the titer of serum HBsAb in congenital HCMV infection group was lower than that in the control group respectively, and there were statistically significant differences (P < 0.01). Conclusions Congenital HCMV infection could weaken the immune effect of hepatitis B vaccine.