›› 2014, Vol. 32 ›› Issue (4): 388-391.

• Original Article • Previous Articles     Next Articles

Research status of genetics and signaling pathways in non-isolated ARM 

Reviewer: SHEN Yujie, Reviser: CHEN Yingwei   

  1.  (Department of Gastroenterology, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai Key Laberatery of Pediatric Gastroenterology and Nutrition, Shanghai 200092, China)
  • Received:2014-04-15 Online:2014-04-15 Published:2014-04-15

Abstract: Anorectal malformations (ARM) are the most common congenital gastrointestinal malformation and can be classified into isolated and non-isolated ARM. Studies so far suggest that ARM represents a multifactorial disorder in which genetic alterations plays an important role in the genesis and development. In this review, we examine hereditary factors and the underlying signaling pathways involved in non-isolated ARM to provide a genetic basis for further study.