›› 2014, Vol. 32 ›› Issue (5): 401-404.

• Original Article •     Next Articles

Treatment of childhood and adolescent mature B-cell lymphoma 

GAO Yijin   

  1. (Shanghai Children’s Medical Center, Shanghai Jiaotong University, School of Medicine, Shanghai 200127, China)
  • Received:2014-04-01 Online:2014-05-15 Published:2014-05-15

Abstract: Mature B-cell non-Hodgkin lymphoma (B-NHL) represents about 55%-60% of all NHL cases in children and adolescents. Burkitt lymphoma and diffuse large B-cell lymphoma are the most common subtypes. Current combination chemotherapy regimen succeeds in overall survival rates of more than 80%. Risk factors for the prognosis of childhood and adolescent B-NHL include, bone marrow and central nervous system involvement, serum lactate dehydrogenase level and kinetics of response to therapy. Future strategies should include further understanding of the genetic alternation of B-NHL and utilization of novel target therapies to decrease treatment-related toxicity. We performed a retrospective analysis on the treatment of child and adolescent mature B-cell lymphoma.