›› 2014, Vol. 32 ›› Issue (5): 413-416.

• Original Article • Previous Articles     Next Articles

Outcome of children with low- or intermediate-risk neuroblastoma: a report of 70 cases

 Tang Yanjing, Pan Ci, Xue Huiliang, Chen Jing, Dong Lu, Zhou Min, Ye Qidong, Shen Shuhong, Wang Yao-ping, Gu Longjun, Tang Jingyan    

  1. (Department of Hematology and Oncology, Shanghai Children's Medical Center, Shanghai Jiaotong University School of Medicine, Shanghai 200127, China)
  • Received:2013-11-09 Online:2014-05-15 Published:2014-05-15

Abstract:  Objectives To evaluate the long-term outcomes of childhood low or intermediate risk neuroblastoma (NB) and their relevant prognostic factors. Methods Total 70 new cases of low or intermediate risk NB diagnosed and treated by NB-99 protocol between 1999 and 2008 were analyzed retrospectively. Results Of these 70 NB patients, fourteen patients were in low risk group and 56 were in intermediate risk group. 67 patients reached complete remission (CR) or very good partial remission (VGPR) and 3 (5%) achieved partial remission (PR). Ten patients relapsed. One patient occured second malignant neoplasm. No patients died of chemotherapy-related adverse events or infections the 5 year overall survival rate was 85.9%, event-free survival rate was 81.0%. Bone marrow infiltration, age at diagnosis, stage, lactate dehydrogenase level had a significant effect on prognosis. Conclusion Develop cytogenetic and molecular biology tests and pretreatment risk stratification are important for further improve treatment protocol.