›› 2014, Vol. 32 ›› Issue (5): 417-420.

• Original Article • Previous Articles     Next Articles

Clinical analysis of childhood hepatoblastoma

HOU Weina1, ZOU Xiang1, GUO Jia1, WANG Lu1, SHENG Guangyao1, SUN Suke2   

  1. (1.Department of Pediatrics, the FirstAffiliated Hospital of Zhengzhou University , Zhengzhou 450052, China; 2. Key Disciplines Laboratory of Henan Clinical Medicine, Zhengzhou 450052, China)
  • Received:2013-11-09 Online:2014-05-15 Published:2014-05-15

Abstract:  Objective To investigate the rational treatment strategy of hepatoblastoma (HB) in children. Methods Clinical data and follow-up of 25 children with HB admitted from February 2009 to March 2013 were retrospectively analyzed. Results Twenty-five children with newly diagnosed HB (14 males and 11 females) were enrolled. The median age on diagnosis was 25 months (3-92 months); In 18 of 25 cases with complete resection of the primary tumor, 17 cases survived. Only 1 of 7 cases with incomplete resection survived. The survival rate in children with complete resection of primary tumor is significantly higher than those without complete resection (P<0.05). The survival rate in children of stage I or II is significantly higher than the children of stage III or IV (P<0.05). Conclusions Complete tumor resection is the cornerstone of therapy for long-term disease-free survival in HB patients. Treatment strategy remains to be further improved for children with recurrent and metastatic HB.