Table of Content

15 April 2016 Volume 34 Issue 4

  

The prevalence of astrovirus, sapovirus, and adenovirus enteric infections in children with acute diarrhea in Chongqing in 2014

CHEN Wanbing, YU Feng, QIAO Yingqin, XU Hongmei

. 2016, 34(4):  241.  doi:10.3969 j.issn.1000-3606.2016.04.001

Abstract ( 328 )   PDF (1360KB) ( 373 )  

Related Articles | Metrics

Objective To investigate the epidemic characteristics of astrovirus (HAstrV), sapovirus(SLV), and adenovirus(HAdV) enteric infections that cause acute diarrhea in children in Chongqing. Methods Children younger than  5-year-old with acute diarrhea were recruited in Chongqing in 2014. Fecal samples were detected by nucleic acid tests. The prevalent time of three viruses and the age and gender of infected patients were analyzed. Results In 511 patients (290 males and 221 females), the positive rate of SLV was 4.7% (24/511), in which the dominant strains were GI.1 and GI.2. The positive rate of HAdV was 2.9% (15/511), in which the dominant strains were HAdV-40 and 41. The positive rate of HAstrV was 2.7% (14/511), in which the dominant strain was HAstrV-1. Patients with co-infection were not found. There were no significant differences of the infection rates between females and males in the three types of viruses (P > 0.05). The highest positive rate of SLV was in November and the highest positive rate of HAstrV was in January. The positive rate of HAdV was not different among different months. All of the positive patients were younger than 36 months. SLV infection existed mainly in 13-36 month old children. Conclusions SLV, HAstrV and HAdV are three important pathogens in acute diarrhea in Chongqing. HAdV5, 7 and 31 also cause acute diarrhea, which need long-term monitoring to verify.

Clinical characteristics and drug resistance pattern of Salmonella infection in children

WANG Tingting, XU Fei, LI Mei, GUO Hongmei

. 2016, 34(4):  246.  doi:10.3969 j.issn.1000-3606.2016.04.002

Abstract ( 413 )   PDF (1139KB) ( 467 )  

Related Articles | Metrics

Objective To explore the epidemiological characteristics and drug resistance pattern of Salmonella infection in children. Methods The clinical features and the results of serotype and drug sensitive tests in hospitalized children having Salmonella strains detected in fecal samples were analyzed from February 2012 to September 2014. Results A total of 87 strains of salmonella were detected in the fecal samples of 2678 participants. Sixty-four strains (73.56%) were detected from May to September. Among 87 salmonella infectious cases (58 males and 29 females), 68 cases (78.16%) were under 2 years old. The major clinical symptoms were mucopurulent stool (65 cases, 74.17%) and fever (72 cases, 82.76%), and there also was rotavirus infection (10 cases, 11.49%). According to serological identification, there were 6 strains of Salmonella Buridan, 6 strains of Salmonella enteritidis, 5 strains of Salmonella typhimurium, 3 strains of Salmonella Arizona, 2 strains of Salmonella oranienburg, 2 strains of Salmonella Tsevie, and one strain each of New Laneige Salmonella, Salmonella derby, Salmonella agona, and Salmonella braenderup. Drug sensitivity tests showed that the rates of Salmonella resistant to cefazolin, cefuroxime, and gentamicin were 94.25%, 87.36%, and 87.36%, respectively. Moreover, 26 strains (29.89%) were multi-drug resistant. Conclusions Children under 2 years old are susceptible to Salmonella infection with males as majority. The common symptoms were mucopurulent stool and fever, and some may be accompanied with rotavirus infection. The common serotypes were Salmonella Buridan, Salmonella enteritidis, and Salmonella typhimurium. The salmonella are resistant to multiple antibiotics and even multi-drug resistant.

Hepatic pathology and genetic testing in one case of medium chain acyl-coenzyme A dehydrogenase deficiency

JIANG Tao, OUYANG Wenxian, TANG Yanfang, YUAN Heli, LI Shuangjie

. 2016, 34(4):  249.  doi:10.3969 j.issn.1000-3606.2016.04.003

Abstract ( 372 )   PDF (1849KB) ( 365 )  

Related Articles | Metrics

Objective To explore the diagnosis and treatment of medium chain acyl-CoA dehydrogenase deficiency (MCADD). Methods The clinical symptoms, laboratory examination and gene detection in one case of MCADD was analyzed retrospectively. The related literatures were reviewed. Results A male child aged 3 years presented transient hypoglycemia, hyperammonemia, and liver dysfunction. Tandem mass chromatography detected acetyl carnitine and multiple acyl carnitines increase in blood. However, the gas chromatography-mass spectrometry showed normal results in urine. Gene testing found a homozygous mutation in acyl-Coenzyme A dehydrogenase (ACADM), c.572G > A p. (Trp191*). The hepatic pathology showed mild damage in hepatocyte, with degrees II inflammation and degree I fibrosis. After treatment of protecting liver and reducing enzyme, and carnitine supplementation, as well as the diet with high carbohydrate, high protein, and low fat, the liver function of the patient was back to normal. Conclusion The use of tandem mass chromatography in blood and gene detection could make a diagnosis of MCADD. Supplement of high energy nutrients and carnitine were benefit to prevent the progress of MCADD.

3β-hydroxy-Δ⁵-C₂₇ steroid dehydrogenase deficiency in one family: two cases report

WU Yi, LI Xuesong, LIU Yan, HUANG Zhihua

. 2016, 34(4):  253.  doi:10.3969 j.issn.1000-3606.2016.04.004

Abstract ( 393 )   PDF (2871KB) ( 375 )  

Related Articles | Metrics

Objective To discuss the clinical features, hepatic ultrastructure, and prognosis of 3β-hydroxy-Δ5-C27 steroid dehydrogenase deficiency caused by mutation of HSD3B7 in children. Methods Clinical features of 3β-hydroxy-Δ5-C27 steroid dehydrogenase deficiency in two children from one family were analyzed retrospectively. The related literatures were also reviewed. Results Two children in one family had different degrees of cholestasis, hepatomegaly, growth retardation, and renal cyst. The serum transaminases was elevated, and the γ-glutamyl GGT (γ-GT) and total bile acid were normal. The hepatic pathology showed intrahepatic cholestasis, inflammatory cell infiltration, hyperplasia of smooth endoplasmic reticulum, increase of glycogenosome, and expansion and hyperplasia of bile capillary. Gene testing found homozygous mutation of HSD3B7 (c.130_131insA) in both children. Conclusions It should be alerted to the possibility of the bile acid synthesis disorder, when infants have cholestasis, elevated transaminase, hepatomegaly, and normal or reduced γ-GT and total bile acid. Gene testing should be completed as soon as possible for early diagnose and therapy.

Clinical diagnosis and treatment of tachyarrhythmia in 107 pediatric patients

XU Meng, XIAO Tingting, SHEN Jie, HUANG Min, XIE Lijian, WANG Jianyi

. 2016, 34(4):  258.  doi:10.3969 j.issn.1000-3606.2016.04.005

Abstract ( 285 )   PDF (1514KB) ( 327 )  

Related Articles | Metrics

Objective To discuss the diagnosis, treatment, and outcomes of pediatric tachyarrhythmia. Methods Clinical data of 107 pediatric inpatients with tachyarrhythmia from January 2011 to December 2014 were retrospectively analyzed. According to 24 hours holter, all patients were divided into two groups, incessant group whose supraventricular tachyrhythmia were more than 50% of heart rate, and intermittent group whose ventricular tachycardia were more than 10%. The clinical features were compared between two groups. Results In a total of 107 patients (64 male and 43 female), there were 31 cases in incessant group with the median age of 7 months which included 13 cases of paroxysmal supraventricular tachycardia (PSVT), 13 cases of atrial tachycardia (AT), 2 cases of chaotic atrial tachycardia (CAT), 1 case of atrial fibrillation (Af), 1 case of junctional ectopic tachycardia (JET), and 1 case of ventricular tachycardia (VT). Among them, 21 cases (67.7%) were progressed to tachycardiainduced cardiomyopathy. There were 76 cases in intermittent group with the median age of 6 years which included 55 cases of PSVT, 4 case of AT, 2 cases of CAT, 5 cases of atrial flutter (AF) (2 cases combined with Af), one case of Af, 3 cases of JET, and 6 cases of VT. 14 cases received monotherapy and 17 cases received combination drug therapy in incessant group. Meanwhile, 61 cases received monotherapy and 11 cases received combination drug therapy in intermittent group. In two groups, because the symptoms of tachyarrhythmias could not be controlled effectively, 17 cases had to treat by transesophageal atrial pacing, 3 cases treated by electrical cardioversion, 2 cases treated by cardiac temporary pacing, and 30 cases treated by radiofrequency ablation. In 6 months of follow-up, one case of VT relapsed, 2 cases of AF and one case of JET controlled ventricular rate in incessant group, while 7 cases of PSVT and one cases of VT relapsed, one cases of AF controlled ventricular rate, and 2 cases of PSVT and VT abandoned therapy and died respectively in intermittent group. The sinus rhythms were recovered in remaining cases. There were statistical differences in age, proportion of PSVT and other rapid arrhythmia, proportion of serum level of cTnI ≥ 0.30 ng/ml, proportion of serum level of NT-proBNP≥ 250 pg/ml, and proportion of monotherapy or combination drug therapy between two groups (P < 0.05). Conclusions It was difficult to treat intermittent rapid arrhythmia, which required combination drug therapy and was prone to develop into tachycardia-induced cardiomyopathy.

Retrospective analysis of etiology of severe pneumonia in children in Chongqing

PU Kaibin, HUANG Ying

. 2016, 34(4):  264.  doi:10.3969 j.issn.1000-3606.2016.04.006

Abstract ( 291 )   PDF (1170KB) ( 228 )  

Related Articles | Metrics

Objective To investigate the etiology of severe pneumonia in children in Chongqing. Methods The data of pathogen detection from 222 hospitalized children with sever pneumonia were retrospectively analyzed from January to December 2012. Results In 222 children, the deep airway specimens were cultured positive in 181 children (81.5%), 87 cases (48.1%) of bacterial infections, 22 cases (12.2%) of virus, 10 cases (5.5%) of fungi, 8 cases (4.4%) of mycoplasma pneumonia, one case (0.6%) of chlamydia trachomatis, and 53 cases (29.3%) of mixed infections. A total of 282 pathogen strains were identified in 181 positive children, 176 strains (62.4%) of bacteria including 140 strains of gram-negative bacteria and 36 strains of gram positive bacteria, with Klebsiella pneumoniae (43 strains) and Streptococcus pneumoniae (20 strains) being the most common, 70 strains (24.8%) of virus with respiratory syncytial virus (RAV, 43 strains) being the most common, 22 (7.8%) strains of fungi with Candida albicans being the most common, 13 (4.6%) strains of Mycoplasma pneumoniae, and one strain (0.4%)  of Chlamydia trachomatis. Bacteria strains were detected positive most often in autumn and winter, totally 40 cases (46.0%). Virus or mixed infections occurred mainly in winter and spring, 14 cases (63.6%) and 39 cases (73.6%) respectively. Virus infections were mainly in infants (one to 12 months old), while Mycoplasma pneumoniae infections were mainly in children aged 3-14 years. Among 181 children, 59 children received mechanical ventilation treatment, and 79 pathogen strains were detected. Different from children with non-mechanical ventilation, the gram positive bacteria were mainly Staphylococcus aureus and virus were mainly adenovirus in children with mechanical ventilation. Conclusions Severe pneumonias are mainly caused by bacterial infections in Chongqing and Klebsiella pneumoniae is the most common, followed by Streptococcus pneumoniae. Staphylococcus aureus and adenovirus infections should be considered in children with mechanical ventilation.

Research in the relationship of inflammatory mediators with serum Gd-IgA1 and NF-κB in children with Henoch-Schönlein purpura

HUA Ran, LU Ling

. 2016, 34(4):  268.  doi:10.3969 j.issn.1000-3606.2016.04.007

Abstract ( 299 )   PDF (6244KB) ( 233 )  

Related Articles | Metrics

Objective To investigate the changes of serum levels of galactose-de?cient IgA1 (Gd-IgA1) and nuclear factor-kappa B ((NF-κB) in children with Henoch-Schönlein purpura (HSP), and the relationships of them with inflammatory mediators. Methods A total of 70 hospitalized children with HSP were recruited from October 2014 to March 2015, and divided into general group (23 cases), gastrointestinal group (21 cases) and nephritis group (26 cases). Meanwhile, 17 healthy children were selected as control group. The serum levels of Gd-IgA1, NF-κB, IL-8, TNF-α, and ICAM-1 were detected by ELISA method. Results In the acute phase of HSP, the serum levels of Gd-IgA1, NF-κB, IL-8, TNF-α, and ICAM-1 were significantly  different among general group, gastrointestinal group, nephritis group and control group (P all < 0.01). The serum levels of Gd-IgA1, NF-κB, IL-8, TNF-α, and ICAM-1 were significantly higher in nephritis group than those in control group (P all < 0.05). In the recovery phase of HSP, the serum levels of Gd-IgA1, NF-κB, TNF-α, and IL-8 in nephritis group were still higher than those in control group (P all < 0.05), but the level of ICAM-1 was no differenct among four groups (P > 0.05). There was a positively correlation between Gd-IgA1 and NF-κB in acute phase in children with HSP (r = 0.67, P < 0.05). Conclusions Gd-IgA1 may up-regulate IL-8, TNF-α, and ICAM-1 by activating NF-κB, resulting in small vascular inflammatory injury of HSP.

Event related potentials study in children with attention deficit hyperactivity disorder or comorbid oppositional defiant disorder

FENG Tingting, ZHANG Jingsong, WANG Zhouye, SHUAI Lan, XIA Weiping

. 2016, 34(4):  273.  doi:10.3969 j.issn.1000-3606.2016.04.008

Abstract ( 318 )   PDF (1221KB) ( 413 )  

Related Articles | Metrics

Objective To investigate the differences of the ability to monitor and resolve the conflicts among children with attention deficit hyperactivity disorder (ADHD), ADHD comorbid oppositional defiant disorder (ODD), and normal children. Methods Event related potentials (ERP) were recorded in fifteen children with ADHD, 18 children with ADHD comorbid ODD, and 18 normal children. Results ERP results showed that the “Go” stimulation time were significantly longer and the correct rates were significantly lower in ADHD group and ADHD comorbid ODD group than those in control group. There were no differences in “Nogo” stimulation time and correct rate among ADHD group, ADHD comorbid ODD group and control group. Latency periods of Go-N2 and Nogo-N2 were significantly longer in ADHD group and ADHD comorbid ODD group than those in control group. However, there was no difference between ADHD group and ADHD comorbid ODD group. Amplitudes of Nogo-P3b were significantly smaller in ADHD group and ADHD comorbid ODD group than those in control group. There was no difference between ADHD group and ADHD comorbid ODD group. Conclusion In children with ADHD, the ability of conflict monitoring was delayed and the ability of conflict resolving was diminished, especially in the second half procession of conflict.

The clinical features and electroencephalographic characteristics of perioral myoclonia with absences in 2 cases

WANG Xiaoyu, LU Xiaopeng, CHEN Jing

. 2016, 34(4):  278.  doi:10.3969 j.issn.1000-3606.2016.04.009

Abstract ( 326 )   PDF (1982KB) ( 298 )  

Related Articles | Metrics

Objective To investigate the clinical features, electroencephalographic (EEG) characteristics, and treatment of perioral myoclonia with absences (POMA). Methods The clinical features, EEG characteristics, and treatment in two pediatric patients with POMA were retrospectively analyzed. The related literatures were reviewed. Results In two pediatric patients POMA were onset with febrile convulsion. The clinical features were that perioral muscles were contracted rhythmically accompanied by absence and disturbance of consciousness. The episodes were frequent, each lasting a few to 10 seconds. The EEG characteristics during attack phase were generalized discharges of 3 Hz spikes and wave burst, while during interictal phase they were medium-high amplitude spine-slow waves, slow wave dissemination or short array. Brain MRIs were normal. One patient had slightly delayed mental and motor development. One patient had a family history of epilepsy. Both of them were treated with sodium valproate and the seizure was controlled. However, one patient relapsed after drug withdrawal. Conclusions POMA is an idiopathic comprehensive epilepsy syndrome featured by perioral myoclonus with absence. The video-EEG is of great value in diagnosis.

Mitochondrial acetoacetyl-CoA thiolase deficiency: report of three cases in a family and literature review

HU Yuhui, CUI Dong, LIU Lin, CHEN Shuli

. 2016, 34(4):  282.  doi:10.3969 j.issn.1000-3606.2016.04.010

Abstract ( 369 )   PDF (1420KB) ( 473 )  

Related Articles | Metrics

Objectives To investigate the diagnosis and prognosis of mitochondrial acetoacetyl-CoA thiolase deficiency (T2 deficiency). Methods The clinical data from three cases in one pedigree were retrospectively analyzed. The related literatures were reviewed. Results Case 1 and 2 were probands, male and monozygotic twins. They were hospitalized because of fever, vomiting, and shortness of breath. The blood gas analysis showed a severely metabolic acidosis. The urine gas chromatography mass spectrometry analysis showed significantly higher level of 3-hydroxybutyrate, 2-methyl-3-hydroxybutyrate, tiglyglycine-1 and 3-tiglyglycine-1, and slightly elevated dicarboxylic acid. The blood tandem mass spectrometry analysis showed significantly increase of C5:1, C5-OH and C4-OH. Case 3 was the older sister of the twins, and was hospitalized because of severely metabolic acidosis at 5 months old. The ACAT1 gene analysis of 3 cases revealed the compound heterozygosity of c.622 C > T (p R208X) and c.653 C > T(p S218F). Conclusions T2 deficiency should be considered in children with an outstanding manifestation of acidosis. Urine gas chromatography mass spectrometry analysis and blood tandem mass spectrometry analysis should be performed for early diagnosis and treatment.

The expression and function of survivin protein in viral myocarditis

YU Qinmei, WU Tingting, ZHU Feng, XIE Yuan, WU Rongzhou

. 2016, 34(4):  292.  doi:10.3969 j.issn.1000-3606.2016.04.012

Abstract ( 260 )   PDF (1624KB) ( 234 )  

Related Articles | Metrics

Objective To explore the expression and possible mechanism of survivin protein in viral myocarditis (VMC). Methods The VMC cell model was created by infecting primary cardiac myocyte with Coxsackie virus (CVB3) in SD neonatal rats. Morphology and pulsation of myocardial cells were observed at 0, 12, 24, 36, 48, 60 hours after infected by CVBs. The degree of injury of myocardial cells was evaluated by lactic dehydrogenase (LDH) enzyme release test. Cell apoptosis was assessed by flow cytometry (FCM). And the expression levels of survivin protein and Cleaved-caspase-3 were detected by Western blot. Results At 48 hours after infected by CVB3, primary myocardial cells in neonatal rat were observed to gradually shrink and became round, and simultaneously, the beating rate was decreased and became irregular. At 60 hours after infected, most cells stopped beating, dropped off from the cell wall, and were dissolved. The cell apoptosis reached the peak (35.85%±3.76%) at 60 hours after infected. The expression of survivin protein was significantly increased after infected, and reached the peak (1.88± 0.39) at 12 hours after infected, which was 1.88 times higher than control group. After that, the expression of survivin protein was decreased and reached its minimum value (0.47±0.41) at 60 hours after infected. The expression of cleaved-caspase-3 was also elevated after infected, and reached the peak at 60 hours (3.46±0.16) after infected. The expression of surviving protein in myocardial cells were negatively correlated with cell apoptosis and the expression of cleaved-caspase-3 (r = －0.727, －0.677, P all < 0.01). Conclusion The expression of survivin protein increases in VMC, which may be involved in the anti-myocardial apoptosis at early stage.

The effect of low molecular weight heparin combined with pulmonary surfactant on acute pulmonary embolism in young rats

DUAN Yang, SUN Fuqiang, QUE Shengshun, LI Yueqin

. 2016, 34(4):  297.  doi:10.3969 j.issn.1000-3606.2016.04.013

Abstract ( 221 )   PDF (1668KB) ( 199 )  

Related Articles | Metrics

Objective To investigate the effect of low molecular weight heparin (LMH) combined with pulmonary surfactant (PS) on acute pulmonary embolism in young rats. Methods Forty-five 4-week-old male SD rats were randomly divided into control group, pulmonary embolism group, LMH group, PS group, LMH-PS group, 9 rats each. Except in the control group, the gelatin sponge particles were injected through jugular vein to make acute pulmonary embolism model. After the injection, LMH group was injected subcutaneously with 0.01 ml LMH /kg twice a day; PS group was perfused intratracheally with 120 mg PS/kg , once a day; LMH-PS group was treated with both LMH and PS. The control group was administrated the same volume of normal saline through jugular vein. On day 1, 4, 7 after injection, the arterial blood gas was analyzed, the pulmonary artery pressure (mPAP) and right ventricular pressure (RVP) were measured, the protein and gene expression levels of ET-1, MMP-9 were detected, and hematoxylin and eosin stain of lung tissue was performed. Results There were statistical differences in PaO2 among the 5 groups on day 1, 4 and 7 (P all < 0.05). On day 1 and 4, the level of PaO2 in LMH-PS was 85.4±6.8 mmHg and 87.8±4.7 mmHg which were significantly higher than in pulmonary embolism group, LMH group and PS group, but lower than in control group (P all < 0.05). There was significant difference in the mPAP on day 1 after injection between LMH-PS group and control group (P < 0.05), and then there were no differences on day 4 and 7 between two groups (P all > 0.05). However, the mPAP was still significantly lower in LMH-PS group than in other three groups (P < 0.05). The expression levels of mRNA and protein of ET-1 and MMP-1 on day 4 and 7 were statistically different among the 5 groups (P all < 0.05). Moreover, the expressions of mRNA and protein of ET-1 were lower in LMH-PS group than in other three groups except the control group. Conclusion LMH combined with PS could effectively treat acute pulmonary embolism in young rats.

Establishment of a mouse model of eosinophilic gastroenteritis induced by ovalbumin

ZENG Yongmei, YANG Sufang, ZHONG Wanying, GENG Lanlan, YANG Min, CHEN Peiyu, ZHANG Jiyong, GONG Sitang

. 2016, 34(4):  303.  doi:10.3969 j.issn.1000-3606.2016.04.014

Abstract ( 308 )   PDF (1922KB) ( 444 )  

Related Articles | Metrics

Objective To create a mouse model of eosinophilic gastroenteritis induced by ovalbumin. Methods Twenty 6-week-old female BALB/c mice were randomly divided into experiment and control groups. The experiment group was intraperitoneally injected with ovalbumin (OVA) and Al(OH)3 as basic sensitization on day 1, and then intraperitoneally injected with OVA and normal saline as strengthening sensitization on day 15. The control group was intraperitoneally injected the same volume of normal saline. During days 18 to 30, the experiment group was challenged 7 times by intragastric injection of OVA encapsulated by PLGA and normal saline every other day . The control group was intragastrically injected with same volume of normal saline. During the molding period, fecal occult blood was detected and activity index score was counted. On day  31, all mice were sacrificed. The serum eosinophils (EOS) was detected. The tissues of stomach, ileum and colon were taken to evaluate the pathological changes and EOS density under light microscope. Results Mice in the experiment group showed piloerection, roachback and lazy. The rat’s weigh was not different between two groups. The score of DAI was higher in experiment group than that in control group (P < 0.01). The EOS count in peripheral blood was not different between two groups (P > 0.05). Under light microscope, the density of ESO in gastrointestinal mucosa was higher in experiment group than that in control group (P < 0.05). The injury was more severe in gastrointestinal mucosa in experiment group than that in control group. Conclusion Intraperitoneal injection of OVA and Al(OH)3 and then being challenged seven times by gavage with OVA wrapped by PLGA every other day, could successfully create a eosinophillic gastroenteritis model.

Advances in the enteral nutrition therapy in pediatric patients with Crohn’s disease

ZHENG Cuifang

. 2016, 34(4):  307.  doi:10.3969 j.issn.1000-3606.2016.04.015

Abstract ( 299 )   PDF (1136KB) ( 471 )  

Related Articles | Metrics

At least 25% of Crohn’s disease (CD) were onset during the childhood, and reach its peak at growth spurt puberty which also is the critical periods of emotional and physical development. Almost all children with CD have growth retardation, malnutrition, micronutrients deficiency, even overweight or obesity at diagnosis and during subsequent courses of disease. The latest inflammatory bowel disease (IBD) nutrition guideline indicated that all patients should be screened for risk of malnutrition at admission and periodically followed-up using a validated screening tool. ECCO/ESPGHAN latest guideline announced that exclusive enteral nutrition (EEN) should be used as the first-line treatment in pediatric patients with CD. Studies had confirmed that EEN was superior to hormone in inducing mucosal healing, restoring bone density, and promoting growth and development without hormone related adverse reactions. This article reviews the progress in application of EEN in pediatric patients with CD.

The epigenetic regulation of SWI/SNF chromatin remodeling complex dependent cardiac development and pathological remodeling

LI Yifei, ZHOU Kaiyu

. 2016, 34(4):  312.  doi:10.3969 j.issn.1000-3606.2016.04.016

Abstract ( 378 )   PDF (1182KB) ( 230 )  

Related Articles | Metrics

With the rapid development of epigenetics, the importance of gene transcription regulated by chromatin remodeling has been noticed recently. The SWI/SNF chromatin remodeling complex has been identified as the most crucial complex in gene regulation with highly conserved structure among species, which alter the activities of genes by shifting the microstructure of DNA, regulating gene expression. A series studies have proved that SWI/SNF chromatin remodeling complex and the main functions of the subunitstook parts in the procedure of heart development, functional mature and pathological remodeling, and have made several breakthroughs. These findings provide a new theoretical and experimental support for the occurrence and development of heart disease.This article aims to review the research progress of SWI/SNF chromatin remodeling complex in regulating heart development and pathological remodeling.