Abstract: General rules for infant formula for special medical purposes were published by National Health and Family Planning Commission of the People’s Republic of China in 2010. Lactose-free or low lactose formula is suggested to be a part of treatment in bottle-fed infants with acute diarrhea. Lactase is suggested to be taken before each feeding in breastfeeding infants with acute diarrhea. Partial hydrolyzed formula (pHF) can be added when the breast milk is insufficient and it is mainly used during the transition from extensively hydrolyzed formula to standard formula during allergy treatment. Extensively hydrolyzed formula should be suggested as the nutritional support during milk avoidance for most of cow’s milk allergy infants. Amino acid formula is the clinical tool to diagnose the cow’s milk allergy and provides the nutritional support to severe cow’s milk allergy infants. Although preterm/low birth weight formula can decrease the rate of the extrauterine growth retardation and sustain the fast growth of preterm babies with insufficient breast milk, Breast-milk with fortifier is strongly recommended as the main nutritional support to keep preterm and low birth weight infants’ growth. Infants with disorders of amino acid catabolism should choose specific formula.