Abstract: 　Objective　To investigate the clinical characteristics, diagnosis and the differential diagnosis of Graves’ disease complicated with systemic lupus erythematosus (SLE) in children. Methods A child diagnosed of Graves’ disease complicated with SLE were reviewed. Results A 13-year-old girl, with fever and convulsions as the onset symptom, had the following examines performed: T3, T4, TSH, brain MRI, TPOAb, TGAb, anti-dsDNA, anti-smDNA, anti-ENA antibodies, antinuclear antibodies, renal and thyroid biopsies. SLE with lupus nephritis, Graves’ disease, cerebral infarction and cerebral white matter demyelination were diagnosed. Conclusions In addition to common diseases, autoimmune disease should also be considered for children with long-time fever and convulsions. Autoantibodies should be checked for children diagnosed of autoimmune thyroid disease.