Abstract: 　Objective　to evaluate the influence of atopy on exhaled nitric oxide in chronic persistent asthmatic children. Methods A total of 52 chronic persistent asthmatic children who completed FeNO measurements and skin prick testing were enrolled. Patients were divided into non-atopic group and atopic group by skin prick testing results, and subdivided into non- allergic rhinitis and rhinitis group according to whether combined with allergic rhinitis. At the same time 78 healthy children were chosen as control group. Moreover, 32 chronic persistent asthmatic children who completed FeNO measurements twice interval of three months were enrolled. Results The FeNO level was significantly different among the atopic group (n=40), the non-atopic group (n=12) and the control group (H=33.29, P=0.000); The FeNO level was significantly higher in the atopic group than that in the non-atopic group (P<0.05). And the FeNO level were significantly different among the rhinitis group (n=41), the non- rhinitis group (n=11) and the control group (H=30.63, P=0.000). The FeNO level was significantly higher in the rhinitis group than that in the control group (P<0.05), however there were no difference between the rhinitis group and the non- rhinitis group(P>0.05).There were no correlations between FeNO levels of chronic persistent asthmatic children and the wheal diameter of house dust mites or dust mites (r=2.05, P=0.135; r=1.58, P=0.312). Moreover, the FeNO level was significantly lower after 3 months ICS treatment (z=-2.05, P=0.041). Conclusions Atopy had major influence on the FeNO level of chronic persistent asthmatic children, and the FeNO level declined with the theatment of ICS.