Abstract: 　Tigecycline is a new class of antimicrobials called glycylcyclines, which has been reported to have a specific antibacterial mechanism with a wide spectrum and low resistance rate. In adults, tigecycline safety and efficacy data were widely known. However, its use in children has been extremely limited because of lacking experience on its effects on tooth development and other clinical data in children. When no other alternative antibacterial agents could be chosen due to multidrugresistant bacterial infections, tigecycline would became an available approach to treat severe infections in children. This article offers an overview on tigecycline off-label uses, dosage and safety, and provides evidences for the choice of antibiotics in pediatric patients with severe infections.