Abstract: 　Objectives　To compare the clinical features between rhinovirus and respiratory syncytial virus infection in lower respiratory tract in children. Methods　From December 2012 to May 2013, direct immunofluorescence assay was performed to test RSV in 1 037 nasal aspirate specimens with LRTIs. RT-PCR method was used to test HRV RNA. The medical records of patients with a positive test of HRV or RSV were reviewed and compared. Results　The isolating rate for HRV and RSV was 8.78% (91/1 037) and 17.16% (178/1 037) respectively. The frequency of co-infection of HRV with other virus was 18.68%, higher than that of RSV (7.30%, χ² =7.867, P=0.005). The age distribution had significant difference between children infected with HRV and RSV (Z=5.40, P<0.001). 78.38% patients with HRV infection were younger than 3 years old, and 83.03% patients with RSV infection were younger than 1 year old. Dyspnea, hyoxemia and wheezing were more common in patients with RSV infection. Admission occurred much later in the course of the HRV infection (P<0.01). Leukocytosis, eosinophi-lia, and an elevated total serum IgE were more common in patients with HRV infection (P<0.05). Conclusions　HRV is one of the important causes of LRTIs in Suzhou. The susceptible population, clinical presentation and laboratory results of HRV infections are different from that of RSV infections.