Abstract: Objective　To investigate the clinical characteristics and resistance of Pseudomonas aeruginosa (PA) bloodstream infections in children. Methods　The clinical data from 54 hospitalized children of PA bloodstream infections were retrospectively analyzed. Results　Of them, 2 cases were septicemia, 51 cases were sepsis, 1 case was bacteremia. 34 cases had underlying diseases, and 20 cases occurred in previously healthy children. All the children had a fever. The other main symptoms were poor spirit and reaction, diarrhea and skin damage, and the proportion of the above symptoms was significantly higher in previously healthy group than in underlying disease group, the difference was statistically significant (P<0.05). Of the 54 patients, 44 (81.48%) had other system involvement, the most common is vulnerable respiratory system, followed by electrolyte imbalance, hematological system and multiple organ failure. In the previously healthy group, the incidence of respiratory, hematological, nervous, circulatory, digestive system and skin damage, multiple organ failure and electrolyte imbalance were significantly higher than that of the underlying disease group, the difference was statistically significant (P<0.05). The albumin in the previously healthy group decreased more, and the median level of CRP and PCT was higher, the difference was statistically significant (P<0.05). Improper antibiotic treatments were found in 23 cases, the highest resistance was Aztreonam, followed by Ceftazidime, and Piperacillin. Poor prognosis was observed in 23 cases. Conclusions　PA bloodstream infections in children are prone to multiple organ damage, and with high rate of improper use of antibiotics and poor prognosis.

Key words: Pseudomonas aeruginosa;　bloodstream infections;　clinical characteristics;　resistance;　child