Abstract: To explore the effect of hybrid approach on the initial management of hypoplastic left heart syndrome (HLHS). Methods The clinical data of a child with HLHS treated with hybrid approach as an alternative to stage I Norwood procedure were retrospectively analyzed. Results Stenting of the ductus arteriosus and bilateral pulmonary artery banding were performed without cardiopulmonary bypass. The total operation time was 105 minutes. The child was discharged from hospital 11 days after operation and remained stable at a 3-month follow-up. Conclusions The hybrid approach may have similar therapeutic effect with stage I Norwood procedure, meanwhile have an effect in avoiding cardiopulmonary bypass, reducing initial mortality and shortening hospital stays.