Abstract: 　Objective　To investigate the clinical features and diagnosis and treatment of spams after herpes simplex encephalitis. Methods　The clinical data of three cases of herpes simplex encephalitis complicated with spasm were retrospectively analyzed, and “herpes simplex encephalitis” “seizures” “spasms” as the keywords were searched on PubMed, CNKI, Wanfang Medical Online and the relevant literatures were reviewed. Results　Three cases of children had a history of childhood herpes simplex viral encephalitis and spasms onset in the infancy stage. The brain MRI showed abnormality. Patient 1 and 2 treated with ACTH showed partial seizure control. Patient 3 received the vagal nerve stimulation. Patient 2 recurred after short-term remission. All the three patients had seizures during the follow-up, and the therapeutic effect was poor. With "herpes simplex encephalitis, epilepsy, spasmodic seizures" as the key words, a total of 3 English literatures were searched on CNKI, Wanfang database and PubMed, 20 children with long-term follow-up were found to have developed into drug-refractory epilepsy with poor prognosis. Conclusion　The drug treatment effect and prognosis of spasms after herpes simplex encephalitis is poor.

Key words: 　herpes simplex encephalitis;　spasms;　treatment