Abstract: Objective To investigate the value of amplitude integrated electroencephalogram (aEEG), advanced oxidation protein product (AOPP) and soluble form of lectin-like oxidized low-density lipoprotein receptor- 1 (sLOX- 1 ) in the early diagnosis of brain injury in preterm infants. Methods A total of 63 premature infants in NICU with high risk of brain injury were selected from September 2018 to September 2019 . According to MRI, the patients were divided into brain injury group ( 27 cases) and non brain injury group ( 30 cases).All of them were detected by aEEG within 6 hours after birth.Meanwhile, plasma was collected at 6 th hour, 3th day and 7th day after the birth of thepremature infants. The indexes were analyzed by logistics and the working characteristic curve of the subjects, and the aEEG, sLOX- 1 and AOPP wereused to calculate the sensitivity, specificity and AUC of single and combined detection. Results There was no significant difference in gestational age, birth weight and gender between the two groups (P> 0 . 05 ). The abnormal rate of aEEG in brain injury group ( 88 . 9 %) was significantly higher than that in non brain injury group ( 26 . 7%) (P< 0 . 001 ). The scores of Cy, Co, B and total of aEEG in brain injury group were significantly lower than those in non brain injury group (P< 0 . 05 ). There was no significant difference in LB between the two groups (P= 0 . 07 ). The levels of sLOX- 1 and AOPP in the plasma of the brain injury group were significantly higher than those of the non brain injury group (P< 0 . 001 ). The sensitivity, specificity and area under the curve of the combined diagnosis were 0 . 93 , 0 . 90 and 0 . 96 , respectively. Conclusion aEEG combined with AOPP and sLOX- 1 can significantly improve the early diagnosis of brain injury in preterm infants, and has a better clinical value in the early diagnosis of brain injury in preterm infants.

Key words: amplitude integrated electroencephalogram; advanced oxidation protein product; soluble form of lectinlike oxidized low-density lipoprotein receptor- 1 ; brain injury; premature infant