Abstract: Objective To explore the clinical characteristics of acute pancreatitis (AP) induced by dyslipidemia in children. Method The clinical data of children diagnosed with AP induced by dyslipidemia from December 2015 to December 2019 were retrospectively analyzed. Results? In 62 cases of confirmed AP, there were 13 cases ( 20. 97%) of AP induced by dyslipidemia and they were 10 boys and 3 girls aged from 2 to 15 years. The course of disease ranged from 1 day to 1 year in 1 severe case and 12 mild cases. There were abdominal pain in 13 cases, nausea and vomiting in 8 cases, protein energy malnutrition in 4 cases and shock in one case. One patient was accompanied by lipoma, hepatosplenomegaly, decreases of red blood cells, white blood cells and platelets. Two cases had obesity and one case had diabetes. There were 4 cases of hypertriglyceridemia, 4 cases of hypercholesterolemia, 3 cases of mixed hyperlipidemia and 2 cases of low-density lipoprotein cholesterol. The whole exon gene tests were performed in 3 patients, among whom two patients with LPL gene variant were diagnosed with familial hyperchylomicemia. Imaging abnormalities were found in 10 cases. B-ultrasonography showed pancreatitis in 9 cases and MRCP showed pancreas enlargement in 8 cases. The treatment included diet management, acid suppression and somatostatin. Two patients received intravenous levocarnitine and oral nicotinamide tablets, and one with severe AP received anti-shock treatment. Clinical remission was achieved in all 13 patients, and one patient relapsed 2 weeks after discharge due to eating a large amount of fish soup. Conclusion Dyslipidemia induced AP in children is not rare and standardized diet guidance is one of the important measures for treatment.

Key words: pancreatitis; hyperlipidemia; child