Abstract: Objective? To investigate the effect of spina bifida occulta on the recurrence of monosymptomatic nocturnal enuresis in children and its treatment. Methods? A total of 186 children with monosymptomatic nocturnal enuresis from September 2018 to September 2019 were selected, of them 98 children with spina bifida occulta were selected and randomly grouped into a control group (desmopressin group, n= 41 ) and an observation group (desmopressin combined with oxybutynin group, n= 57 ), and all children were given dry bed training. The treatment effect and adverse effects of the children were observed after 6 months of treatment and 3 months of drug withdrawal. Results? After 6 months of treatment, the control group had a complete effect rate of 61. 0% and a total effective rate of 68. 3%; the observation group had a complete effect rate of 80. 7% and a total effective rate of 91.2%. The differences in the complete effect rate (χ2 =4.65, P=0.031) and the total effective rate (χ2 =8.37, P= 0 . 004 ) between the two groups were statistically significant. Three months after discontinuation of the drug, 11 ( 26 . 8%) of the 41 control children relapsed and 6 ( 10. 5%) of the 57 observed children relapsed, with a statistically significant difference between the two groups (χ2 = 4 . 42 , P= 0 . 036 ). Conclusion? Spina bifida occulta was found to be highly prevalent in children with monosymptomatic nocturnal enuresis and to be prone to recurrence of enuresis during treatment. The combination of desmopressin with oxybutynin for the treatment was effective on increasing the complete response rate and efficiency, decreasing the recurrence rate, and on providing good compliance and safety.

Key words: spina bifida occulta;? monosymptomatic nocturnal enuresis;? treatment;? relapse