关于贝利尤单抗治疗儿童狼疮性肾炎的一些个人见解

doi:10.12372/jcp.2025.24e0805

Abstract

Abstract:

Systemic lupus erythematosus (SLE) is one of the most common systemic autoimmune diseases in children. The involvement of the kidneys in systemic lupus erythematosus (SLE) is referred to as lupus nephritis (LN), which serves as a critical factor influencing the prognosis of SLE. Belimumab is a recombinant human IgG1λ monoclonal antibody targeting B-lymphocyte stimulator, which inhibits B cell function by promoting B cell apoptosis. Belimumab can improve the response index and disease activity score of SLE, and delay the progression of LN. As a clinical pediatric nephrologist, the author explores some personal advices on the treatment of LN in children with Belimumab.

Key words: systemic lupus erythematosus, lupus nephritis, belimumab, personal advice

ZHANG Hongwen. Some personal advices on belimumab treatment in childhood lupus nephritis[J].Journal of Clinical Pediatrics, 2025, 43(2): 147-149.

References 20

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Some personal advices on belimumab treatment in childhood lupus nephritis

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