Abstract: 　Objective　To explore the clinical value of early application of general movements (GMs) combined with evoked potentials (EPs) in predicting motor development of high-risk neonates. Methods A total of 112 high-risk neonates in follow-up clinic of pediatric neurological rehabilitation were selected. GMs evaluation and EPs detection were measured in writhing movements period and fidgety movements period respectively. The motor developmental outcomes were determined at the corrected age of 12 months after continuous follow-up according to the diagnostic criteria (2006) of cerebral palsy (CP) and Peabody motor development scale. The predictive validity of GMs, EPs and the combination of GMs and EPs was calculated. Results The motor developmental outcomes of 112 cases showed that there were 26 cases (23.2%) of CP, 14 cases (12.5%) of motor retardation and 72 normal cases (64.3%). In writhing movements period, the predictive validity of GMs in conjunction with median nerve somatosensory evoked potentials (MNSEP) for abnormal motor development was as follows: sensitivity 80%, specificity 98.6%, positive predictive value 97%, and negative predictive value 89.9%. In fidgety movements period, the predictive validity of GMs for CP was as follows: sensitivity 96.1%, specificity 97.7%, positive predictive value 92.6% and negative predictive value 98.8%. However, the predictive validity of the combination of GMs and MNSEP for CP had no significant increase. The predictive validity of MNSEP in both writhing movements period and fidgety movements period for abnormal motor development was as follows: sensitivity 82.5%, specificity 91.7%, positive predictive value 84.6% and negative predictive value 90.4%. Conclusions　In writhing movements period, combination with GMs and MNSEPs can improve the predictive validity for abnormal motor development in high-risk neonates.