Abstract: 　Objective　To study the relationship between ARID5B polymorphisms and the susceptibility of the childhood acute lymphoblastic leukemia (ALL) in Minnan Chinese Han population. Methods　The association analysis between ALL and polymorphisms of ARID5B were performed in a Minnan Han population case-control series using fluorescence resonance energy transfer probes analysis. Results　We analyzed the genotypes of the rs7073837 and rs10821936 in ARID5B in 108 patients with acute lymphoblastic leukemia and 116 ethnically matched controls. The genotype distribution of rs7073837 and rs10821936 in ALL and control groups followed Hardy-Weinberg equilibrium. No significant differences in genotypic and allelic distributions between ALL patients and controls were observed for rs7073837. We found significant differences in genotypic distribution of rs10821936 variant between ALL patients and control subjects (P<0.001), and variant allele C in ALL group was significantly more frequent than that in the controls (P<0.001, Odds ratio=2.203, 95% confidence interval, CI: 1.507-3.220). Conclusions　 Our data suggested that rs10821936 variant in ARID5B plays a potential role in childhood ALL in Minnan Han population, and variant allele C carriers may be at an increased risk of developing ALL. Moreover, no association between rs7073837 and childhood ALL was observed.