Abstract: Objective　To explore the clinical features and factors influencing the prognosis of childhood non-Hodgkin's lymphoma (NHL). Methods　Pathologically diagnosed 78 pediatric patients with NHL and treated in the Affiliated Hospital of Qingdao University from January 2004 to August 2013 were collected and analyzed. Patients were grouped according to age, sex, tumor size, immunologic classification, B-symptoms, LDH, hemoglobin and clinical staging. The 5-years event-free survival rate (EFS) were calculated and analyzed by Kaplan-Meier method, and the difference of the survival rate between groups were compared. Using Cox proportional hazards model, we analyzed the possible factors that might influence 5-years event-free survival rate EFS , such as age and clinical staging. The OR value and the 95% CI were calculated. Results　Among the 78 cases, median age of onset is 7 years old, male to female ratio is 2.90:1, there are 25 cases of T-cell type and 53 cases of B-cell type. According to pathological types，Burkitt lymphoma is the most common (34.6%), followed by T-lymphoblastic lymphoma (20.5%), diffuse large B-cell lymphoma (11.5%). According to the St. Jude malignant lymphoma staging system, there are 2 cases in stage I, 9 in stage Ⅱ , 35 in stage Ⅲ and 32 in stage Ⅳ. Swelling of periphery lymph node (80.7%) was observed as initial symptom in 26 cases of lymphoblastic lymphoma. Among 45 cases of mature B-cell tumor, the main clinical feature including abdominal cavity and gingival were observed in 27 cases of Burkitt lymphoma. Among the 73 cases received treatments, 66 cases (90.5%) attained CR (complete remission) and 4 cases (5.5%) attained PR (partial remission) by cytology and radiographic assessment after two course of combined chemotherapy, 2 cases (2.7%) rapidly relapsed after the remisson of one course treatment, 1 case (1.3%) appeared the central nervous system infiltration in the chemotherapy. With median follow-up time of 42 months, the 5-year EFS of the 73 cases was (67.0+5.5)%. Single factor analysis showed that B-symptom, LDH, and clinical staging were significantly correlated with prognosis (P<0.05), while age, sex, tumor size, hemoglobin and immune classification was independent of prognosis (P>0.05). Multiple factor analysis showed that LDH and clinical staging influenced the prognosis (OR=3.34，95 ％ CI 2.275−10.683，P<0.01；OR=4.354，95%CI 1.519−12.475，P<0.01) . Conclusion　clinical features of childhood NHL are variable. LDH and clinical staging at primary diagnosis are important factors affecting the prognosis.