Abstract: Objectives　To investigate the clinico-radiological characteristics of mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) in children. Methods　The clinical data from 8 children with MERS were retrospectively reviewed. Results　The clinical manifestations of 8 children were 7 cases with serizures, 5 cases with disturbance consciousness. The clinical symptoms disappeared within one week. The underlying diseases were mainly infections in respiratory and digestive tracts. Serum sodium levels <135 mEq/L were observed in 3 cases. According to imaging, 7 children were diagnosed MERS I with lesion only involving the splenium of the corpus callosum, one child was diagnosed MERS II with lesion extended from the splenium of the corpus callosum to the white matter of semi-oval. The lesion had completely disappeared in all children at follow-up MRI exams between 6 days and 1 month after the initial MRI. Conclusion　MERS exhibits acute mild encephalitis/encephalopathy symptoms, which is a clinico-radiological syndrome with good prognosis.