Childhood primary Sjogren syndrome with central nervous system symptoms as the first manifestation: a case report and literature review

  • JIN Yanliang ,
  • MAO Youying ,
  •  HUANG Hua
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  • Shanghai Children’s Medical Central Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200127, China

Received date: 2017-10-15

  Online published: 2017-10-15

Abstract

Objective To explore the diagnosis and treatment of childhood primary Sjogren syndrome (pSS) with central nervous system symptoms as the first manifestation. Methods The clinical data of an 11-year-old male with pSS which had onset with fever and headache was retrospectively analyzed. The related literatures were reviewed. Results The subject was diagnosed with pSS by autoantibody detection, lip biopsy, and ophthalmologic examination. The symptoms were improved after immunosuppressive therapy. According to the literature, the incidence of childhood pSS was low, in which the incidence with involvment of the nervous system as primanry manifestation was even lower, and headache is the most common symptom of central nervous system. The application of corticosteroids and immunosuppressants may help improve the conditions. Conclusions Involvement of central nervous system in childhood pSS is not typical. Detection of autoantibodies and lip biopsy are helpful for diagnosis.

Cite this article

JIN Yanliang , MAO Youying ,  HUANG Hua . Childhood primary Sjogren syndrome with central nervous system symptoms as the first manifestation: a case report and literature review[J]. Journal of Clinical Pediatrics, 2017 , 35(10) : 775 . DOI: 10.3969/j.issn.1000-3606.2017.10.014

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