Advances in insulin-like growth factor-1 in hypoxic-ischemic encephalopathy

  • WU Nan ,
  • CHEN Ting
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  • 1.The First Clinical Medical College of Lanzhou University, Lanzhou 730000, Gansu, China; 2.The First Affiliated of Lanzhou University, Lanzhou 730000, Gansu, China

Received date: 2017-11-15

  Online published: 2017-11-15

Abstract

 Hypoxic-ischemic encephalopathy (HIE) is a common cause of neonatal mortality and neurological sequelae. Insulin-like growth factor-1 (IGF-1) is a neurotrophic factor and anti-apoptotic factor that plays an important role in the development and maturation of the central nervous system. In this paper, we intended to provide a new idea and recent progress of HIE by illustrating the mechanism of action of IGF-1 in neuroprotection, nerve repair and neovascularization after brain hypoxia-ischemia injury.

Cite this article

WU Nan , CHEN Ting . Advances in insulin-like growth factor-1 in hypoxic-ischemic encephalopathy[J]. Journal of Clinical Pediatrics, 2017 , 35(11) : 868 . DOI: 10.3969/j.issn.1000-3606.2017.11.017

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