Objective　To analysis the association between nephrotic syndrome (NS) and Hodgkin lymphoma. Methods　The clinical data of one child with clinical manifestations of NS before diagnosed Hodgkin's lymphoma were retrospectively analyzed. Results　A 3-year and 8-month-old boy, with NS as the first onset symptom, was poor response to hormone therapy. Hodgkin's lymphoma was diagnosed with cervical lymph node biopsy. After chemotherapy, the symptoms were relieved and the renal function turned to normal. Conclusion　NS can be a paraneoplastic performance of Hodgkin's lymphoma.