Analysis of the risk factors of intravenous immunoglobin-resistant Kawasaki diseases

  • ZHAO Wenlong ,
  • ZHANG Zhengyu ,
  • SHI Qinlin ,
  • WU Ziming ,
  • LUO Zhaoyang
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  • 1. Department of Health Decision Making, School of Medical Informatics, Chongqing Medical University, Chongqing 400016, China; 2. Children's Hospital of Chongqing Medical University, Chongqing 400014, China

Received date: 2018-01-15

  Online published: 2018-01-15

Abstract

Objective To explore the early laboratory indicators for risk of intravenous immunoglobin-resistant Kawasaki diseases. Methods The clinical data were retrospectively analyzed in 881 Kawasaki disease patients (group A: 26 cases of intravenous immunoglobin-resistant; group B: 855 cases of intravenous immunoglobin-sensitive) from July 1, 2015 to June 30, 2016. After 1:3 matching with age and sex, the regression model for each of variables including sex, age, fever days, temperature, red blood cell count (RBC), white blood cell count (WBC), neutrophil (N), lymphocyte (L), platelet count (PLT) and C reactive protein (CRP), was constructed by conditional logistic regression analysis. Results Compared with group B, group A had significantly lower RBC count and higher PLT (P<0.05). Logistic regression analysis showed that, with the age, the regression model was Y=-2.87+0.01×PLT (PLT OR=1.01, 95%CI: 1.00~1.01, P<0.01); with the sex, Y=-32.98+0.44×WBC+0.28×          N+0.01×PLT (WBC OR=1.55, 95%CI: 1.17~2.05, P<0.01; N% OR=1.32, 95%CI: 1.04~1.68, P<0.05; PLT OR=1.01, 95%CI 1.00~1.01, P<0.01). Conclusion In case that abnormally high levels of PLT exist in confirmed Kawasaki disease, it should be aware of possibility of the intravenous immunoglobin-resistant Kawasaki disease.

Cite this article

ZHAO Wenlong , ZHANG Zhengyu , SHI Qinlin , WU Ziming , LUO Zhaoyang . Analysis of the risk factors of intravenous immunoglobin-resistant Kawasaki diseases[J]. Journal of Clinical Pediatrics, 2018 , 36(1) : 1 . DOI: 10.3969/j.issn.1000-3606.2018.01.001

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