Progress on minimal residual diseases in childhood solid tumor

  •  ZHAO Jie
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  • Department of Hematology/ Oncology, Shanghai Children’s Medical Center Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200127, China

Received date: 2018-02-15

  Online published: 2018-02-15

Abstract

 Minimal residual disease (MRD) is a major cause of solid tumor relapse, which refers to the small number of malignant cells remained after therapy that cannot be detected by conventional imaging examination and morphological examination. Whereas flow cytometry and polymerase chain reaction based methods constitute the two most commonly used techniques for MRD detection. Next generation sequencing will certainly be widely employed in individual MRD detection by testing on specific genetic change in the future. This article is to review the progress on MRD detection methods in childhood solid tumor.

Cite this article

 ZHAO Jie . Progress on minimal residual diseases in childhood solid tumor[J]. Journal of Clinical Pediatrics, 2018 , 36(2) : 149 . DOI: 10.3969/j.issn.1000-3606.2018.02.015

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