Norovirus is one of the main pathogens causing nonbacterial gastroenteritis in infants and young children. Clinical symptoms in norovirus infection include nausea, vomiting, diarrhea, abdominal pain among which vomiting is obvious. Due to the lack of effective research models, the pathogenesis of Norovirus infection is still unclear. This article focuses on the progress in research of the pathogenic mechanism of Norovirus, and mainly discusses the cell phagocytosis and immune response.