Objective To explore the outcome of recurrent wheezing and the risk factors of its different phenotypes in young children. Method The children under 5 years old with recurrent wheezing were included from October 2013 to May 2014, and a telephone follow-up was made after 3 years. The incidence of wheezing, rhinitis, eczema and the history of parents' asthma were investigated since the children were enrolled. According to the age at onset and relief of wheezing, the children investigated were divided into transient wheezing group, persistent wheezing group and late-onset wheezing group. The difference of birth history, rhinitis, eczema, parental asthma history, allergy related index and wheezing onset age among three groups were compared. Results In 100 children, 85 children (66 boys and 19 girls) finished a telephone follow-up and the average age was (6.82±1.20) years at follow-up. The onset age of transient wheezing group (14 children) was lower than that in persistent wheezing group (54 children) and late-onset wheezing group (17 children), and there were statistical differences (P<0.05). the number of wheezing in three groups was significantly reduced in the past year, as compared with the number when they were enrolled, and there were statistical differences (P<0.05). The incidence of rhinitis in past year was significantly different among three groups, the incidence being higher in persistent and late-onset wheezing groups being . The total serum IgE, the positive rate of inhaled allergens and the percentage of eosinophils (EOS) in peripheral blood increased across groups with upward trend in transient, persistent and late-onset wheezing, and there were statistical differences (P<0.05). Conclusion The frequency of onset of wheezing was significantly reduced over age in young children, and the outcome of the wheezing was significantly related to allergies, rhinitis, and age at onset.
WANG Huimin
,
ZHU Wenjing
,
LIU Chuanhe
,
MA Hongmei
,
Shao Mingjun
,
Yan Yongdong
,
Chen Yuzhi
,
TIAN Chunyu
. The outcome of recurrent wheezing and the risk factors of its different phenotypes in young children[J]. Journal of Clinical Pediatrics, 2018
, 36(4)
: 272
.
DOI: 10.3969/j.issn.1000-3606.2018.04.009