Objective　To explore the clinical characteristics of Gianotti-Crosti syndrome. Method　The clinical data of Gianotti-Crosti syndrome in 55 children were retrospectively analyzed, and the relevant literature was reviewed. Results　In 55 children (39 boys and 16 girls) diagnosed with Gianotti-Crosti syndrome, an average age was (2.0±0.5) years. EB virus was the most common pathogen, followed by herpes simplex virus, and no hepatitis B virus infection was found. Skin lesions were characterized by symmetrical distribution of erythematous papules on the extensor side of extremities, cheek, and buttocks. All of them received the treatment of antiviral, anti-inflammatory, anti-allergic and topical medication,  and it was effective after 2 weeks of the treatments. The cure rate was 74.5%. Conclusion　The most important onset factor of Gianotti-Crosti syndrome is virus infection, and skin lesion is characterized and the prognosis is good.