Features and clinical significance of IKZF1 aberrations in childhood B-cell acute lymphoblastic leukemia

BI Junqin

doi:10.3969/j.issn.1000-3606.2018.11.019

Journal of Clinical Pediatrics >

2018 , Vol. 36 >Issue 11: 880

DOI: https://doi.org/10.3969/j.issn.1000-3606.2018.11.019

Features and clinical significance of IKZF1 aberrations in childhood B-cell acute lymphoblastic leukemia

BI Junqin

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1.Center for Clinical Molecular Medicine,Ministry of Education Key Laboratory of Child Development Disorders, Chongqing Key Laboratory of Pediatrics, Children’ Hospital of Chongqing Medical University, Chongqing 400014, China; 2.Department of Pathology and Laboratory Medicine and Geisel School of Medicine at Dartmouth College, New Hampshire 03756, USA

Received date: 2018-11-15

Online published: 2018-11-15

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Abstract

　IKAROS family zinc finger 1 （IKZF1） gene encoding a zinc finger transcription factor IKAROS plays an important role in the regulation of B lymphoid cell differentiation and proliferation. IKZF1 is a clinical tumor suppressive factor. Deletion of IKZF1 results in either haploinsufficiency or dominating negative for IKAROS that contributes to the development of B-cell acute lymphoblastic leukemia (B-ALL), associated with an poor prognosis. Study of IKZF1 may lead to identifying new risk stratification molecular indicator for B-ALL for a better guidance to individualized therapy.

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BI Junqin . Features and clinical significance of IKZF1 aberrations in childhood B-cell acute lymphoblastic leukemia[J]. Journal of Clinical Pediatrics, 2018 , 36(11) : 880 . DOI: 10.3969/j.issn.1000-3606.2018.11.019

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