Objective　To analyze the clinical characteristics of Mycoplasma pneumoniae plastic bronchitis. Method　The clinical data of Mycoplasma pneumoniae plastic bronchitis in 5 children were retrospectively analyzed. Results　Five children (4 boys and 1 girl) all had cough and high fever and the fever duration was 5~13 days. Dyspnea and respiratory failure were found in 3 children, toxic hepatitis in 2 children, toxic encephalopathy in 1 child, toxic myocarditis in 1 child, and iliac vein and femoral vein thrombosis in 1 child. Chest imaging examination showed unilateral atelectasis with pulmonary consolidation in 5 children. Plastic bronchitis was confirmed on the 4th to 10th day of the disease course by bronchoscopy. 4 patients had bronchial obstruction and 1 patient had main bronchus obstruction. The plastic body was removed completely by bronchoscopy for 2-4 times. The children were cured clinically and discharged. Conclusion　Plastic bronchitis should be considered in children with Mycoplasma pneumoniae pneumonia combined with dyspnea, unilateral atelectasis/consolidation. Bronchoscopy plays an important role in confirming diagnosis and improving prognosis.