Objective　To explore the value of echocardiography in evaluating the prognosis of left-sided congenital diaphragmatic hernia (CDH) in neonates. Methods　The left-sided CDH neonates born from January 2015 to January 2018 were selected as study subjects, and their general conditions and echocardiographic data were reviewed. According to whether the patients were alive 30 days after birth, they were divided into survival group and death group for comparative analysis. Results　A total of 65 newborns with left-sided CDH were enrolled, including 48 in the survival group and 17 in the death group. Compared with the death group, the survival group had higher gestational age and birth weight, lower proportion of continuous right-to-left shunt of ductus arteriosus, lower trans-tricuspid pressure gradient, larger right pulmonary artery (RPA) diameter and left ventricular end-diastolic diameter (LVDd), and there were significant differences (P<0.05). Multivariate logistic regression analysis showed that trans-tricuspid pressure gradient and LVDd were independent predictors of poor prognosis (P<0.05). Conclusion　Echocardiography plays an important role in evaluating the clinical prognosis of left-sided CDH in neonates.