Objective　To explore the clinical value of extracorporeal membrane oxygenation (ECMO) in the treatment of severe Kawasaki disease shock syndrome (KDSS) complicated with cardiogenic shock. Methods　The clinical characteristics of KDSS complicated with cardiogenic shock in a child and the process of treatment with ECMO were retrospectively analyzed, and the related literature was reviewed. Results　A 4-year-old girl diagnosed with Kawasaki disease did not response to intravenous gamma globulin (IVIG) therapy. Diarrhea, listlessness, decreased blood pressure and multiple organ dysfunction of respiratory, cardiovascular, digestive and renal systems occurred on the 6th day of the course of the disease. The condition was still critical after fluid resuscitation, which was in line with the recommended indications of ECMO cardiac support. After the treatment of veno-arterial (V-A) mode ECMO, the patient's condition was relieved and discharged. Conclusion　Early combined ECMO support therapy may be one of the effective methods for KDSS with cardiogenic shock.